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Caspase-3 activation during apoptosis caused by glutathione–doxorubicin conjugate

Glutathione–doxorubicin (GSH–DXR) effectively induced apoptosis in rat hepatoma cells (AH66) at a lower concentration than DXR. After 24 h of drug treatment, DNA fragmentation of the cells was observed at the concentration of 1.0 μM DXR or 0.01 μM GSH–DXR. Increase in caspase-3 activity and DNA frag...

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Detalles Bibliográficos
Autores principales:	Asakura, T, Sawai, T, Hashidume, Y, Ohkawa, Y, Yokoyama, S, Ohkawa, K
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362273/ https://www.ncbi.nlm.nih.gov/pubmed/10360648 http://dx.doi.org/10.1038/sj.bjc.6690414

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