Deletion mapping of chromosome 16q in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) frequently shows an allelic imbalance (AI) on chromosome 16q. In order to define the commonly affected regions on chromosome 16q, we assessed AI studies in 41 HCCs using a panel of 37 microsatellite markers. Thirty-five cases (85%) showed AI at one or more loci. Among...

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Detalles Bibliográficos
Autores principales: Piao, Z, Park, C, Kim, J J, Kim, H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362275/
https://www.ncbi.nlm.nih.gov/pubmed/10360665
http://dx.doi.org/10.1038/sj.bjc.6690431
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author Piao, Z
Park, C
Kim, J J
Kim, H
author_facet Piao, Z
Park, C
Kim, J J
Kim, H
author_sort Piao, Z
collection PubMed
description Hepatocellular carcinoma (HCC) frequently shows an allelic imbalance (AI) on chromosome 16q. In order to define the commonly affected regions on chromosome 16q, we assessed AI studies in 41 HCCs using a panel of 37 microsatellite markers. Thirty-five cases (85%) showed AI at one or more loci. Among the 35 cases with AI, 21 cases showed multiple AI, suggesting the wide scope of deletion on the long arm of chromosome 16, and the remaining 14 cases showed partial AI. Detailed deletion mapping identified two independent commonly deleted regions on this chromosome arm. These included the D16S3106 locus and D16S498 locus. In conclusion, we have demonstrated frequent AI on 16q in HCCs and identified two loci with frequent AI, which may harbour new tumour suppressor genes. © 1999 Cancer Research Campaign
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spelling pubmed-23622752009-09-10 Deletion mapping of chromosome 16q in hepatocellular carcinoma Piao, Z Park, C Kim, J J Kim, H Br J Cancer Regular Article Hepatocellular carcinoma (HCC) frequently shows an allelic imbalance (AI) on chromosome 16q. In order to define the commonly affected regions on chromosome 16q, we assessed AI studies in 41 HCCs using a panel of 37 microsatellite markers. Thirty-five cases (85%) showed AI at one or more loci. Among the 35 cases with AI, 21 cases showed multiple AI, suggesting the wide scope of deletion on the long arm of chromosome 16, and the remaining 14 cases showed partial AI. Detailed deletion mapping identified two independent commonly deleted regions on this chromosome arm. These included the D16S3106 locus and D16S498 locus. In conclusion, we have demonstrated frequent AI on 16q in HCCs and identified two loci with frequent AI, which may harbour new tumour suppressor genes. © 1999 Cancer Research Campaign Nature Publishing Group 1999-05 /pmc/articles/PMC2362275/ /pubmed/10360665 http://dx.doi.org/10.1038/sj.bjc.6690431 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Piao, Z
Park, C
Kim, J J
Kim, H
Deletion mapping of chromosome 16q in hepatocellular carcinoma
title Deletion mapping of chromosome 16q in hepatocellular carcinoma
title_full Deletion mapping of chromosome 16q in hepatocellular carcinoma
title_fullStr Deletion mapping of chromosome 16q in hepatocellular carcinoma
title_full_unstemmed Deletion mapping of chromosome 16q in hepatocellular carcinoma
title_short Deletion mapping of chromosome 16q in hepatocellular carcinoma
title_sort deletion mapping of chromosome 16q in hepatocellular carcinoma
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362275/
https://www.ncbi.nlm.nih.gov/pubmed/10360665
http://dx.doi.org/10.1038/sj.bjc.6690431
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