Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours

The RCK gene is a target of the t(11;14)(q23;q32) chromosomal translocation observed in human B-cell lymphoma, and the overexpression of its protein (rck/p54) by the translocation was shown to cause malignant transformation. The rck/p54 protein belongs to the DEAD box protein/RNA helicase family, wh...

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Autores principales: Nakagawa, Y, Morikawa, H, Hirata, I, Shiozaki, M, Matsumoto, A, Maemura, K, Nishikawa, T, Niki, M, Tanigawa, N, Ikegami, M, Katsu, K, Akao, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362290/
https://www.ncbi.nlm.nih.gov/pubmed/10360675
http://dx.doi.org/10.1038/sj.bjc.6690441
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author Nakagawa, Y
Morikawa, H
Hirata, I
Shiozaki, M
Matsumoto, A
Maemura, K
Nishikawa, T
Niki, M
Tanigawa, N
Ikegami, M
Katsu, K
Akao, Y
author_facet Nakagawa, Y
Morikawa, H
Hirata, I
Shiozaki, M
Matsumoto, A
Maemura, K
Nishikawa, T
Niki, M
Tanigawa, N
Ikegami, M
Katsu, K
Akao, Y
author_sort Nakagawa, Y
collection PubMed
description The RCK gene is a target of the t(11;14)(q23;q32) chromosomal translocation observed in human B-cell lymphoma, and the overexpression of its protein (rck/p54) by the translocation was shown to cause malignant transformation. The rck/p54 protein belongs to the DEAD box protein/RNA helicase family, which has a variety of functions such as translation initiation, pre-mRNA splicing and ribosome assembly. The expression of rck p54 in colorectal adenocarcinoma cells was examined by immunohistochemistry and Western blot analysis. The rck/p54 protein was found to be overexpressed in tumour tissues resected from 13 (50%) out of 26 cases of colorectal adenocarcinomas and two out of two (100%) cases of colonic severe dysplastic adenomas. In view of activities of rck/p54 determined in other tissue types, we suggest that rck/p54 may contribute to the cell proliferation and carcinogenesis at the translational level in the development of colorectal tumours. © 1999 Cancer Research Campaign
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spelling pubmed-23622902009-09-10 Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours Nakagawa, Y Morikawa, H Hirata, I Shiozaki, M Matsumoto, A Maemura, K Nishikawa, T Niki, M Tanigawa, N Ikegami, M Katsu, K Akao, Y Br J Cancer Regular Article The RCK gene is a target of the t(11;14)(q23;q32) chromosomal translocation observed in human B-cell lymphoma, and the overexpression of its protein (rck/p54) by the translocation was shown to cause malignant transformation. The rck/p54 protein belongs to the DEAD box protein/RNA helicase family, which has a variety of functions such as translation initiation, pre-mRNA splicing and ribosome assembly. The expression of rck p54 in colorectal adenocarcinoma cells was examined by immunohistochemistry and Western blot analysis. The rck/p54 protein was found to be overexpressed in tumour tissues resected from 13 (50%) out of 26 cases of colorectal adenocarcinomas and two out of two (100%) cases of colonic severe dysplastic adenomas. In view of activities of rck/p54 determined in other tissue types, we suggest that rck/p54 may contribute to the cell proliferation and carcinogenesis at the translational level in the development of colorectal tumours. © 1999 Cancer Research Campaign Nature Publishing Group 1999-05 /pmc/articles/PMC2362290/ /pubmed/10360675 http://dx.doi.org/10.1038/sj.bjc.6690441 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Nakagawa, Y
Morikawa, H
Hirata, I
Shiozaki, M
Matsumoto, A
Maemura, K
Nishikawa, T
Niki, M
Tanigawa, N
Ikegami, M
Katsu, K
Akao, Y
Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours
title Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours
title_full Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours
title_fullStr Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours
title_full_unstemmed Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours
title_short Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours
title_sort overexpression of rck/p54, a dead box protein, in human colorectal tumours
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362290/
https://www.ncbi.nlm.nih.gov/pubmed/10360675
http://dx.doi.org/10.1038/sj.bjc.6690441
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