Haematogenous cytokeratin 20 mRNA as a predictive marker for recurrence in oral cancer patients

We examined the expression of cytokeratin 20 (CK20) mRNA in the peripheral blood of oral squamous cell carcinoma (SCC) patients by reverse transcriptase polymerase chain reaction (RT-PCR). Eleven out of 12 oral SCC patients showed positive RT-PCR results. However, there is no clear relationship betw...

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Detalles Bibliográficos
Autores principales: Kawamata, H, Uchida, D, Nakashiro, K, Hino, S, Omotehara, F, Yoshida, H, Sato, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362317/
https://www.ncbi.nlm.nih.gov/pubmed/10408852
http://dx.doi.org/10.1038/sj.bjc.6690377
Descripción
Sumario:We examined the expression of cytokeratin 20 (CK20) mRNA in the peripheral blood of oral squamous cell carcinoma (SCC) patients by reverse transcriptase polymerase chain reaction (RT-PCR). Eleven out of 12 oral SCC patients showed positive RT-PCR results. However, there is no clear relationship between the haematogenous CK20 mRNA and the metastasis. After initial treatment, all of the tumour-free survivors tested showed negative RT-PCR results. CK20 mRNA in peripheral blood can be used as a marker for tumour recurrence but not for metastasis in oral SCC patients. © 1999 Cancer Research Campaign

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