Aberrant DNA methylation of the p16(INK4a) gene in plasma DNA of breast cancer patients

Hypermethylation of exon 1 of p16(INK4a) was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of...

Descripción completa

Detalles Bibliográficos
Autores principales: Silva, J M, Dominguez, G, Villanueva, M J, Gonzalez, R, Garcia, J M, Corbacho, C, Provencio, M, España, P, Bonilla, F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362379/
https://www.ncbi.nlm.nih.gov/pubmed/10376981
http://dx.doi.org/10.1038/sj.bjc.6690495
_version_ 1782153443475980288
author Silva, J M
Dominguez, G
Villanueva, M J
Gonzalez, R
Garcia, J M
Corbacho, C
Provencio, M
España, P
Bonilla, F
author_facet Silva, J M
Dominguez, G
Villanueva, M J
Gonzalez, R
Garcia, J M
Corbacho, C
Provencio, M
España, P
Bonilla, F
author_sort Silva, J M
collection PubMed
description Hypermethylation of exon 1 of p16(INK4a) was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16(INK4a) can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients. © 1999 Cancer Research Campaign
format Text
id pubmed-2362379
institution National Center for Biotechnology Information
language English
publishDate 1999
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23623792009-09-10 Aberrant DNA methylation of the p16(INK4a) gene in plasma DNA of breast cancer patients Silva, J M Dominguez, G Villanueva, M J Gonzalez, R Garcia, J M Corbacho, C Provencio, M España, P Bonilla, F Br J Cancer Regular Article Hypermethylation of exon 1 of p16(INK4a) was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16(INK4a) can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients. © 1999 Cancer Research Campaign Nature Publishing Group 1999-06 /pmc/articles/PMC2362379/ /pubmed/10376981 http://dx.doi.org/10.1038/sj.bjc.6690495 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Silva, J M
Dominguez, G
Villanueva, M J
Gonzalez, R
Garcia, J M
Corbacho, C
Provencio, M
España, P
Bonilla, F
Aberrant DNA methylation of the p16(INK4a) gene in plasma DNA of breast cancer patients
title Aberrant DNA methylation of the p16(INK4a) gene in plasma DNA of breast cancer patients
title_full Aberrant DNA methylation of the p16(INK4a) gene in plasma DNA of breast cancer patients
title_fullStr Aberrant DNA methylation of the p16(INK4a) gene in plasma DNA of breast cancer patients
title_full_unstemmed Aberrant DNA methylation of the p16(INK4a) gene in plasma DNA of breast cancer patients
title_short Aberrant DNA methylation of the p16(INK4a) gene in plasma DNA of breast cancer patients
title_sort aberrant dna methylation of the p16(ink4a) gene in plasma dna of breast cancer patients
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362379/
https://www.ncbi.nlm.nih.gov/pubmed/10376981
http://dx.doi.org/10.1038/sj.bjc.6690495
work_keys_str_mv AT silvajm aberrantdnamethylationofthep16ink4ageneinplasmadnaofbreastcancerpatients
AT dominguezg aberrantdnamethylationofthep16ink4ageneinplasmadnaofbreastcancerpatients
AT villanuevamj aberrantdnamethylationofthep16ink4ageneinplasmadnaofbreastcancerpatients
AT gonzalezr aberrantdnamethylationofthep16ink4ageneinplasmadnaofbreastcancerpatients
AT garciajm aberrantdnamethylationofthep16ink4ageneinplasmadnaofbreastcancerpatients
AT corbachoc aberrantdnamethylationofthep16ink4ageneinplasmadnaofbreastcancerpatients
AT provenciom aberrantdnamethylationofthep16ink4ageneinplasmadnaofbreastcancerpatients
AT espanap aberrantdnamethylationofthep16ink4ageneinplasmadnaofbreastcancerpatients
AT bonillaf aberrantdnamethylationofthep16ink4ageneinplasmadnaofbreastcancerpatients

Ejemplares similares