Aberrant DNA methylation of the p16(INK4a) gene in plasma DNA of breast cancer patients

Hypermethylation of exon 1 of p16(INK4a) was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of...

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Detalles Bibliográficos
Autores principales: Silva, J M, Dominguez, G, Villanueva, M J, Gonzalez, R, Garcia, J M, Corbacho, C, Provencio, M, España, P, Bonilla, F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362379/
https://www.ncbi.nlm.nih.gov/pubmed/10376981
http://dx.doi.org/10.1038/sj.bjc.6690495

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