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Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation
Both experimental and clinical research have shown that hyperthermia (HT) gives valuable additional effects when applied in combination with radiotherapy (RT). The purpose of this study was evaluation of results in patients with recurrent breast cancer, treated at the Daniel den Hoed Cancer Center (...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362408/ https://www.ncbi.nlm.nih.gov/pubmed/10027317 http://dx.doi.org/10.1038/sj.bjc.6690075 |
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author | Zee, J van der Holt, B van der Rietveld, P J M Helle, P A Wijnmaalen, A J Putten, W L J van Rhoon, G C van |
author_facet | Zee, J van der Holt, B van der Rietveld, P J M Helle, P A Wijnmaalen, A J Putten, W L J van Rhoon, G C van |
author_sort | Zee, J van der |
collection | PubMed |
description | Both experimental and clinical research have shown that hyperthermia (HT) gives valuable additional effects when applied in combination with radiotherapy (RT). The purpose of this study was evaluation of results in patients with recurrent breast cancer, treated at the Daniel den Hoed Cancer Center (DHCC) with reirradiation (re-RT; eight fractions of 4 Gy twice weekly) combined with HT. All 134 patients for whom such treatment was planned were included in the analysis. The complete response rate in 119 patients with macroscopic tumour was 71%. Including the 15 patients with microscopic disease, the local control rate was 73%. The median duration of local control was 32 months, and toxicity was acceptable. The complete response (CR) rate was higher, and the toxicity was less with the later developed 433-MHz HT technique compared with the 2450-MHz technique used initially. With this relatively well-tolerated treatment, palliation by local tumour control of a worthwhile duration is achieved in the majority of patients. The technique used for hyperthermia appeared to influence the achieved results. The value of HT in addition to this re-RT schedule has been confirmed by a prospective randomized trial in a similar patient group. In The Netherlands, this combined treatment is offered as standard to patients with breast cancer recurring in previously irradiated areas. © 1999 Cancer Research Campaign |
format | Text |
id | pubmed-2362408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23624082009-09-10 Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation Zee, J van der Holt, B van der Rietveld, P J M Helle, P A Wijnmaalen, A J Putten, W L J van Rhoon, G C van Br J Cancer Regular Article Both experimental and clinical research have shown that hyperthermia (HT) gives valuable additional effects when applied in combination with radiotherapy (RT). The purpose of this study was evaluation of results in patients with recurrent breast cancer, treated at the Daniel den Hoed Cancer Center (DHCC) with reirradiation (re-RT; eight fractions of 4 Gy twice weekly) combined with HT. All 134 patients for whom such treatment was planned were included in the analysis. The complete response rate in 119 patients with macroscopic tumour was 71%. Including the 15 patients with microscopic disease, the local control rate was 73%. The median duration of local control was 32 months, and toxicity was acceptable. The complete response (CR) rate was higher, and the toxicity was less with the later developed 433-MHz HT technique compared with the 2450-MHz technique used initially. With this relatively well-tolerated treatment, palliation by local tumour control of a worthwhile duration is achieved in the majority of patients. The technique used for hyperthermia appeared to influence the achieved results. The value of HT in addition to this re-RT schedule has been confirmed by a prospective randomized trial in a similar patient group. In The Netherlands, this combined treatment is offered as standard to patients with breast cancer recurring in previously irradiated areas. © 1999 Cancer Research Campaign Nature Publishing Group 1999-02 /pmc/articles/PMC2362408/ /pubmed/10027317 http://dx.doi.org/10.1038/sj.bjc.6690075 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Zee, J van der Holt, B van der Rietveld, P J M Helle, P A Wijnmaalen, A J Putten, W L J van Rhoon, G C van Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation |
title | Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation |
title_full | Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation |
title_fullStr | Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation |
title_full_unstemmed | Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation |
title_short | Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation |
title_sort | reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362408/ https://www.ncbi.nlm.nih.gov/pubmed/10027317 http://dx.doi.org/10.1038/sj.bjc.6690075 |
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