Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results

Fourteen patients with metastatic pancreatic adenocarcinoma were treated with the long-acting somatostatin (SST) analogue lanreotide. No objective response was obtained, and the median survival was 4 months (range 1.8–7 months). Pancreatic cancer could not be visualized by means of SST-receptor (R)...

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Autores principales: Raderer, M, Hamilton, G, Kurtaran, A, Valencak, J, Haberl, I, Hoffmann, O, Kornek, G V, Vorbeck, F, Hejna, M H L, Virgolini, I, Scheithauer, W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362412/
https://www.ncbi.nlm.nih.gov/pubmed/10027326
http://dx.doi.org/10.1038/sj.bjc.6690084
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author Raderer, M
Hamilton, G
Kurtaran, A
Valencak, J
Haberl, I
Hoffmann, O
Kornek, G V
Vorbeck, F
Hejna, M H L
Virgolini, I
Scheithauer, W
author_facet Raderer, M
Hamilton, G
Kurtaran, A
Valencak, J
Haberl, I
Hoffmann, O
Kornek, G V
Vorbeck, F
Hejna, M H L
Virgolini, I
Scheithauer, W
author_sort Raderer, M
collection PubMed
description Fourteen patients with metastatic pancreatic adenocarcinoma were treated with the long-acting somatostatin (SST) analogue lanreotide. No objective response was obtained, and the median survival was 4 months (range 1.8–7 months). Pancreatic cancer could not be visualized by means of SST-receptor (R) scintigraphy in our patients. In vitro data also demonstrated absence of SSTR2 expression, suggesting pancreatic cancer not to be a potential target for treatment with SST analogues. © 1999 Cancer Research Campaign
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spelling pubmed-23624122009-09-10 Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results Raderer, M Hamilton, G Kurtaran, A Valencak, J Haberl, I Hoffmann, O Kornek, G V Vorbeck, F Hejna, M H L Virgolini, I Scheithauer, W Br J Cancer Regular Article Fourteen patients with metastatic pancreatic adenocarcinoma were treated with the long-acting somatostatin (SST) analogue lanreotide. No objective response was obtained, and the median survival was 4 months (range 1.8–7 months). Pancreatic cancer could not be visualized by means of SST-receptor (R) scintigraphy in our patients. In vitro data also demonstrated absence of SSTR2 expression, suggesting pancreatic cancer not to be a potential target for treatment with SST analogues. © 1999 Cancer Research Campaign Nature Publishing Group 1999-02 /pmc/articles/PMC2362412/ /pubmed/10027326 http://dx.doi.org/10.1038/sj.bjc.6690084 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Raderer, M
Hamilton, G
Kurtaran, A
Valencak, J
Haberl, I
Hoffmann, O
Kornek, G V
Vorbeck, F
Hejna, M H L
Virgolini, I
Scheithauer, W
Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results
title Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results
title_full Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results
title_fullStr Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results
title_full_unstemmed Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results
title_short Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results
title_sort treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362412/
https://www.ncbi.nlm.nih.gov/pubmed/10027326
http://dx.doi.org/10.1038/sj.bjc.6690084
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