Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma

Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance...

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Detalles Bibliográficos
Autores principales: Ribatti, D, Vacca, A, Nico, B, Quondamatteo, F, Ria, R, Minischetti, M, Marzullo, A, Herken, R, Roncali, L, Dammacco, F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362443/
https://www.ncbi.nlm.nih.gov/pubmed/10027312
http://dx.doi.org/10.1038/sj.bjc.6690070
Descripción
Sumario:Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules. © 1999 Cancer Research Campaign

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