Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma

Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance...

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Autores principales: Ribatti, D, Vacca, A, Nico, B, Quondamatteo, F, Ria, R, Minischetti, M, Marzullo, A, Herken, R, Roncali, L, Dammacco, F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362443/
https://www.ncbi.nlm.nih.gov/pubmed/10027312
http://dx.doi.org/10.1038/sj.bjc.6690070
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author Ribatti, D
Vacca, A
Nico, B
Quondamatteo, F
Ria, R
Minischetti, M
Marzullo, A
Herken, R
Roncali, L
Dammacco, F
author_facet Ribatti, D
Vacca, A
Nico, B
Quondamatteo, F
Ria, R
Minischetti, M
Marzullo, A
Herken, R
Roncali, L
Dammacco, F
author_sort Ribatti, D
collection PubMed
description Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules. © 1999 Cancer Research Campaign
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spelling pubmed-23624432009-09-10 Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma Ribatti, D Vacca, A Nico, B Quondamatteo, F Ria, R Minischetti, M Marzullo, A Herken, R Roncali, L Dammacco, F Br J Cancer Regular Article Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules. © 1999 Cancer Research Campaign Nature Publishing Group 1999-02 /pmc/articles/PMC2362443/ /pubmed/10027312 http://dx.doi.org/10.1038/sj.bjc.6690070 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Ribatti, D
Vacca, A
Nico, B
Quondamatteo, F
Ria, R
Minischetti, M
Marzullo, A
Herken, R
Roncali, L
Dammacco, F
Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
title Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
title_full Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
title_fullStr Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
title_full_unstemmed Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
title_short Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
title_sort bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362443/
https://www.ncbi.nlm.nih.gov/pubmed/10027312
http://dx.doi.org/10.1038/sj.bjc.6690070
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