Cargando…

Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia

Despite improvement in diagnostic modalities, confirmation of a histologic diagnosis of cancer of the biliary tree and pancreas remains elusive. Attempts to collect positive cytology specimens from vigorous brushings or washings obtained at endoscopy or percutaneously are often unsuccessful. In our...

Descripción completa

Detalles Bibliográficos
Autores principales: Siegel, Jerome H., Veerappan, Annamali, Prudente, Romulo, Kasmin, Franklin E., Cohen, Seth A.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362474/
https://www.ncbi.nlm.nih.gov/pubmed/18493350
http://dx.doi.org/10.1155/DTE.1.107
_version_ 1782153463122100224
author Siegel, Jerome H.
Veerappan, Annamali
Prudente, Romulo
Kasmin, Franklin E.
Cohen, Seth A.
author_facet Siegel, Jerome H.
Veerappan, Annamali
Prudente, Romulo
Kasmin, Franklin E.
Cohen, Seth A.
author_sort Siegel, Jerome H.
collection PubMed
description Despite improvement in diagnostic modalities, confirmation of a histologic diagnosis of cancer of the biliary tree and pancreas remains elusive. Attempts to collect positive cytology specimens from vigorous brushings or washings obtained at endoscopy or percutaneously are often unsuccessful. In our unit, we have increased the yield by obtaining tissue scraped from prostheses that have been previously placed in either the bile duct or the pancreatic duct. The stents are first flushed with saline to collect cytology specimens, after which, they are bisected and scraped, and these contents are prepared in a manner similar to that used to prepare biopsy samples. Twelve of 16 scraped samples, 9 bile duct and 3 pancreas, were positive for adenocarcinoma. The cytology specimens were positive in only 4 of the 12. We recommend this method of sampling from material contained within prostheses as an adjunct when previous brushings, washings, or biopsies are negative.
format Text
id pubmed-2362474
institution National Center for Biotechnology Information
language English
publishDate 1994
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-23624742008-05-20 Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia Siegel, Jerome H. Veerappan, Annamali Prudente, Romulo Kasmin, Franklin E. Cohen, Seth A. Diagn Ther Endosc Research Article Despite improvement in diagnostic modalities, confirmation of a histologic diagnosis of cancer of the biliary tree and pancreas remains elusive. Attempts to collect positive cytology specimens from vigorous brushings or washings obtained at endoscopy or percutaneously are often unsuccessful. In our unit, we have increased the yield by obtaining tissue scraped from prostheses that have been previously placed in either the bile duct or the pancreatic duct. The stents are first flushed with saline to collect cytology specimens, after which, they are bisected and scraped, and these contents are prepared in a manner similar to that used to prepare biopsy samples. Twelve of 16 scraped samples, 9 bile duct and 3 pancreas, were positive for adenocarcinoma. The cytology specimens were positive in only 4 of the 12. We recommend this method of sampling from material contained within prostheses as an adjunct when previous brushings, washings, or biopsies are negative. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2362474/ /pubmed/18493350 http://dx.doi.org/10.1155/DTE.1.107 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Siegel, Jerome H.
Veerappan, Annamali
Prudente, Romulo
Kasmin, Franklin E.
Cohen, Seth A.
Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia
title Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia
title_full Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia
title_fullStr Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia
title_full_unstemmed Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia
title_short Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia
title_sort stent scraping for histology: an alternative method for obtaining tissue to rule out neoplasia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362474/
https://www.ncbi.nlm.nih.gov/pubmed/18493350
http://dx.doi.org/10.1155/DTE.1.107
work_keys_str_mv AT siegeljeromeh stentscrapingforhistologyanalternativemethodforobtainingtissuetoruleoutneoplasia
AT veerappanannamali stentscrapingforhistologyanalternativemethodforobtainingtissuetoruleoutneoplasia
AT prudenteromulo stentscrapingforhistologyanalternativemethodforobtainingtissuetoruleoutneoplasia
AT kasminfrankline stentscrapingforhistologyanalternativemethodforobtainingtissuetoruleoutneoplasia
AT cohensetha stentscrapingforhistologyanalternativemethodforobtainingtissuetoruleoutneoplasia