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Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia
Despite improvement in diagnostic modalities, confirmation of a histologic diagnosis of cancer of the biliary tree and pancreas remains elusive. Attempts to collect positive cytology specimens from vigorous brushings or washings obtained at endoscopy or percutaneously are often unsuccessful. In our...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
1994
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362474/ https://www.ncbi.nlm.nih.gov/pubmed/18493350 http://dx.doi.org/10.1155/DTE.1.107 |
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author | Siegel, Jerome H. Veerappan, Annamali Prudente, Romulo Kasmin, Franklin E. Cohen, Seth A. |
author_facet | Siegel, Jerome H. Veerappan, Annamali Prudente, Romulo Kasmin, Franklin E. Cohen, Seth A. |
author_sort | Siegel, Jerome H. |
collection | PubMed |
description | Despite improvement in diagnostic modalities, confirmation of a histologic diagnosis of cancer of the biliary tree and pancreas remains elusive. Attempts to collect positive cytology specimens from vigorous brushings or washings obtained at endoscopy or percutaneously are often unsuccessful. In our unit, we have increased the yield by obtaining tissue scraped from prostheses that have been previously placed in either the bile duct or the pancreatic duct. The stents are first flushed with saline to collect cytology specimens, after which, they are bisected and scraped, and these contents are prepared in a manner similar to that used to prepare biopsy samples. Twelve of 16 scraped samples, 9 bile duct and 3 pancreas, were positive for adenocarcinoma. The cytology specimens were positive in only 4 of the 12. We recommend this method of sampling from material contained within prostheses as an adjunct when previous brushings, washings, or biopsies are negative. |
format | Text |
id | pubmed-2362474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1994 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23624742008-05-20 Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia Siegel, Jerome H. Veerappan, Annamali Prudente, Romulo Kasmin, Franklin E. Cohen, Seth A. Diagn Ther Endosc Research Article Despite improvement in diagnostic modalities, confirmation of a histologic diagnosis of cancer of the biliary tree and pancreas remains elusive. Attempts to collect positive cytology specimens from vigorous brushings or washings obtained at endoscopy or percutaneously are often unsuccessful. In our unit, we have increased the yield by obtaining tissue scraped from prostheses that have been previously placed in either the bile duct or the pancreatic duct. The stents are first flushed with saline to collect cytology specimens, after which, they are bisected and scraped, and these contents are prepared in a manner similar to that used to prepare biopsy samples. Twelve of 16 scraped samples, 9 bile duct and 3 pancreas, were positive for adenocarcinoma. The cytology specimens were positive in only 4 of the 12. We recommend this method of sampling from material contained within prostheses as an adjunct when previous brushings, washings, or biopsies are negative. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2362474/ /pubmed/18493350 http://dx.doi.org/10.1155/DTE.1.107 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Siegel, Jerome H. Veerappan, Annamali Prudente, Romulo Kasmin, Franklin E. Cohen, Seth A. Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia |
title | Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia |
title_full | Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia |
title_fullStr | Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia |
title_full_unstemmed | Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia |
title_short | Stent Scraping for Histology: An Alternative Method for Obtaining Tissue to Rule out Neoplasia |
title_sort | stent scraping for histology: an alternative method for obtaining tissue to rule out neoplasia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362474/ https://www.ncbi.nlm.nih.gov/pubmed/18493350 http://dx.doi.org/10.1155/DTE.1.107 |
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