Photodynamic Therapy of Lung Cancer With Bronchial Artery Infusion of Photofrin

Photodynamic therapy (PDT) utilizing Photofrin is proving to be effective for the treatment of early stage lung cancer. However, wider clinical applications of Photofrin as a photosensitizer for various cancers are hampered by potentially serious and prolonged skin photosensitivity. To prevent these...

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Detalles Bibliográficos
Autores principales: Okunaka, Tetsuya, Kato, Harubumi, Konaka, Chimori, Furukawa, Kinya, Harada, Masahiko, Yamamoto, Yutaka
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362536/
https://www.ncbi.nlm.nih.gov/pubmed/18493405
http://dx.doi.org/10.1155/DTE.2.203
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author Okunaka, Tetsuya
Kato, Harubumi
Konaka, Chimori
Furukawa, Kinya
Harada, Masahiko
Yamamoto, Yutaka
author_facet Okunaka, Tetsuya
Kato, Harubumi
Konaka, Chimori
Furukawa, Kinya
Harada, Masahiko
Yamamoto, Yutaka
author_sort Okunaka, Tetsuya
collection PubMed
description Photodynamic therapy (PDT) utilizing Photofrin is proving to be effective for the treatment of early stage lung cancer. However, wider clinical applications of Photofrin as a photosensitizer for various cancers are hampered by potentially serious and prolonged skin photosensitivity. To prevent these side effects and reduce the hospitalization period, we recently gave reduced doses of Photofrin by bronchial arterial infusion. Five patients with endoscopically evaluated minimally invasive carcinoma of the lung were given 0.7 mg/kg of Photofrin by bronchial arterial infusion 48 hr before PDT. Complete remission was obtained in all 5 cases and no case showed skin photosensitivity when exposed to sunlight under careful surveillance at one week after PDT.
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spelling pubmed-23625362008-05-20 Photodynamic Therapy of Lung Cancer With Bronchial Artery Infusion of Photofrin Okunaka, Tetsuya Kato, Harubumi Konaka, Chimori Furukawa, Kinya Harada, Masahiko Yamamoto, Yutaka Diagn Ther Endosc Research Article Photodynamic therapy (PDT) utilizing Photofrin is proving to be effective for the treatment of early stage lung cancer. However, wider clinical applications of Photofrin as a photosensitizer for various cancers are hampered by potentially serious and prolonged skin photosensitivity. To prevent these side effects and reduce the hospitalization period, we recently gave reduced doses of Photofrin by bronchial arterial infusion. Five patients with endoscopically evaluated minimally invasive carcinoma of the lung were given 0.7 mg/kg of Photofrin by bronchial arterial infusion 48 hr before PDT. Complete remission was obtained in all 5 cases and no case showed skin photosensitivity when exposed to sunlight under careful surveillance at one week after PDT. Hindawi Publishing Corporation 1996 /pmc/articles/PMC2362536/ /pubmed/18493405 http://dx.doi.org/10.1155/DTE.2.203 Text en Copyright © 1996 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Okunaka, Tetsuya
Kato, Harubumi
Konaka, Chimori
Furukawa, Kinya
Harada, Masahiko
Yamamoto, Yutaka
Photodynamic Therapy of Lung Cancer With Bronchial Artery Infusion of Photofrin
title Photodynamic Therapy of Lung Cancer With Bronchial Artery Infusion of Photofrin
title_full Photodynamic Therapy of Lung Cancer With Bronchial Artery Infusion of Photofrin
title_fullStr Photodynamic Therapy of Lung Cancer With Bronchial Artery Infusion of Photofrin
title_full_unstemmed Photodynamic Therapy of Lung Cancer With Bronchial Artery Infusion of Photofrin
title_short Photodynamic Therapy of Lung Cancer With Bronchial Artery Infusion of Photofrin
title_sort photodynamic therapy of lung cancer with bronchial artery infusion of photofrin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362536/
https://www.ncbi.nlm.nih.gov/pubmed/18493405
http://dx.doi.org/10.1155/DTE.2.203
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AT konakachimori photodynamictherapyoflungcancerwithbronchialarteryinfusionofphotofrin
AT furukawakinya photodynamictherapyoflungcancerwithbronchialarteryinfusionofphotofrin
AT haradamasahiko photodynamictherapyoflungcancerwithbronchialarteryinfusionofphotofrin
AT yamamotoyutaka photodynamictherapyoflungcancerwithbronchialarteryinfusionofphotofrin

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