A Clinical Study of Photodynamic Therapy for Superficial Esophageal Carcinoma by YAG-OPO Laser

A cooperative clinical study of photodynamic therapy (PDT) for superficial esophageal carcinoma was conducted at 6 medical institution. PHE (2mg/kg) with high tumor affinity was used as the oncotropic compound. The light source was a pulse wave YAG-OPO laser with high penetration into the tissue. Ir...

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Detalles Bibliográficos
Autores principales: Yoshida, Kazunari, Suzuki, Shigeru, Mimura, Seishiro, Narahara, Hiroyuki, Tanimura, Hiroshi, Nagai, Yugo, Isono, Kaichi, Kozu, Teruo, Fukutomi, Hisayuki, Nakahara, Akira, Kashimura, Hiromasa, Hirashima, Toshio, Murata, Yoko, Ide, Hiroko, Kato, Harubumi
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362605/
https://www.ncbi.nlm.nih.gov/pubmed/18493469
http://dx.doi.org/10.1155/DTE.4.173
Descripción
Sumario:A cooperative clinical study of photodynamic therapy (PDT) for superficial esophageal carcinoma was conducted at 6 medical institution. PHE (2mg/kg) with high tumor affinity was used as the oncotropic compound. The light source was a pulse wave YAG-OPO laser with high penetration into the tissue. Irradiation was performed at an energy density of 60–180 J/cm(2) 48–72 h after PHE administration. Eight lesions in 6 patients were treated. All were type 0-II superficial carcinomas. The depth of invasion was EP–MM for 6 lesions and SM for 2 lesions. A complete response (CR) was achieved in all patients after one session of PDT. Five adverse events, including anemia and fever, were reported by 4 patients, but all were WHO grade 2 or lower and transient. PDT using PHE and YAG-OPO laser was therefore considered effective as a curative therapy for superficial esophageal carcinoma.

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