Oestrogen receptor-α variant mRNA expression in primary human breast tumours and matched lymph node metastases

We have shown previously that the relative expression of a truncated oestrogen receptor-α variant mRNA (ER clone 4) is significantly increased in axillary node-positive primary breast tumours compared with node-negative tumours. In this study, we have examined the relative expression of clone 4-trun...

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Detalles Bibliográficos
Autores principales: Leygue, E, Hall, R E, Dotzlaw, H, Watson, P H, Murphy, L C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362647/
https://www.ncbi.nlm.nih.gov/pubmed/10070900
http://dx.doi.org/10.1038/sj.bjc.6690156
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author Leygue, E
Hall, R E
Dotzlaw, H
Watson, P H
Murphy, L C
author_facet Leygue, E
Hall, R E
Dotzlaw, H
Watson, P H
Murphy, L C
author_sort Leygue, E
collection PubMed
description We have shown previously that the relative expression of a truncated oestrogen receptor-α variant mRNA (ER clone 4) is significantly increased in axillary node-positive primary breast tumours compared with node-negative tumours. In this study, we have examined the relative expression of clone 4-truncated, exon 5-deleted and exon 7-deleted oestrogen receptor-α variant mRNAs in 15 primary breast tumour samples and in synchronous axillary lymph node metastases. Overall, there were no significant differences between the primary tumours and the matched metastases in the relative expression of these three specific variant mRNAs. Furthermore, the pattern of all deleted oestrogen receptor-α variant mRNAs appeared conserved between any primary and its matched secondary tumour. © 1999 Cancer Research Campaign
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spelling pubmed-23626472009-09-10 Oestrogen receptor-α variant mRNA expression in primary human breast tumours and matched lymph node metastases Leygue, E Hall, R E Dotzlaw, H Watson, P H Murphy, L C Br J Cancer Regular Article We have shown previously that the relative expression of a truncated oestrogen receptor-α variant mRNA (ER clone 4) is significantly increased in axillary node-positive primary breast tumours compared with node-negative tumours. In this study, we have examined the relative expression of clone 4-truncated, exon 5-deleted and exon 7-deleted oestrogen receptor-α variant mRNAs in 15 primary breast tumour samples and in synchronous axillary lymph node metastases. Overall, there were no significant differences between the primary tumours and the matched metastases in the relative expression of these three specific variant mRNAs. Furthermore, the pattern of all deleted oestrogen receptor-α variant mRNAs appeared conserved between any primary and its matched secondary tumour. © 1999 Cancer Research Campaign Nature Publishing Group 1999-02 /pmc/articles/PMC2362647/ /pubmed/10070900 http://dx.doi.org/10.1038/sj.bjc.6690156 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Leygue, E
Hall, R E
Dotzlaw, H
Watson, P H
Murphy, L C
Oestrogen receptor-α variant mRNA expression in primary human breast tumours and matched lymph node metastases
title Oestrogen receptor-α variant mRNA expression in primary human breast tumours and matched lymph node metastases
title_full Oestrogen receptor-α variant mRNA expression in primary human breast tumours and matched lymph node metastases
title_fullStr Oestrogen receptor-α variant mRNA expression in primary human breast tumours and matched lymph node metastases
title_full_unstemmed Oestrogen receptor-α variant mRNA expression in primary human breast tumours and matched lymph node metastases
title_short Oestrogen receptor-α variant mRNA expression in primary human breast tumours and matched lymph node metastases
title_sort oestrogen receptor-α variant mrna expression in primary human breast tumours and matched lymph node metastases
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362647/
https://www.ncbi.nlm.nih.gov/pubmed/10070900
http://dx.doi.org/10.1038/sj.bjc.6690156
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