High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma

Benzoporphyrin derivative monoacid ring A (verteporfin, BPD-MA) when intravenously injected (5.5 μmol kg(−1)) to C57/BL6 mice bearing a subcutaneously transplanted B1 melanoma gave a maximal accumulation in the tumour within 1–3 h with recoveries of 1.84– 1.96 μmol kg(−1). Irradiation of BPD-MA-load...

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Detalles Bibliográficos
Autores principales: Busetti, A, Soncin, M, Jori, G, Rodgers, M A J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362652/
https://www.ncbi.nlm.nih.gov/pubmed/10070875
http://dx.doi.org/10.1038/sj.bjc.6690131
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author Busetti, A
Soncin, M
Jori, G
Rodgers, M A J
author_facet Busetti, A
Soncin, M
Jori, G
Rodgers, M A J
author_sort Busetti, A
collection PubMed
description Benzoporphyrin derivative monoacid ring A (verteporfin, BPD-MA) when intravenously injected (5.5 μmol kg(−1)) to C57/BL6 mice bearing a subcutaneously transplanted B1 melanoma gave a maximal accumulation in the tumour within 1–3 h with recoveries of 1.84– 1.96 μmol kg(−1). Irradiation of BPD-MA-loaded melanoma with 690-nm light from a dye laser at 3 h and 9 h post injection induced tumour necrosis and delay of tumour growth of 28 and 14 days respectively. The response of the tumour to BPD-MA photosensitization was enhanced by pretreatment with 1064-nm light from a pulse-operated Nd:YAG laser, which caused a selective breakdown of melanosomes. © 1999 Cancer Research Campaign
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spelling pubmed-23626522009-09-10 High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma Busetti, A Soncin, M Jori, G Rodgers, M A J Br J Cancer Regular Article Benzoporphyrin derivative monoacid ring A (verteporfin, BPD-MA) when intravenously injected (5.5 μmol kg(−1)) to C57/BL6 mice bearing a subcutaneously transplanted B1 melanoma gave a maximal accumulation in the tumour within 1–3 h with recoveries of 1.84– 1.96 μmol kg(−1). Irradiation of BPD-MA-loaded melanoma with 690-nm light from a dye laser at 3 h and 9 h post injection induced tumour necrosis and delay of tumour growth of 28 and 14 days respectively. The response of the tumour to BPD-MA photosensitization was enhanced by pretreatment with 1064-nm light from a pulse-operated Nd:YAG laser, which caused a selective breakdown of melanosomes. © 1999 Cancer Research Campaign Nature Publishing Group 1999-02 /pmc/articles/PMC2362652/ /pubmed/10070875 http://dx.doi.org/10.1038/sj.bjc.6690131 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Busetti, A
Soncin, M
Jori, G
Rodgers, M A J
High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma
title High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma
title_full High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma
title_fullStr High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma
title_full_unstemmed High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma
title_short High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma
title_sort high efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362652/
https://www.ncbi.nlm.nih.gov/pubmed/10070875
http://dx.doi.org/10.1038/sj.bjc.6690131
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