Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma

We examined a panel of sporadic breast carcinomas for loss of heterozygosity (LOH) in a 10-cM interval on chromosome 10 known to encompass the PTEN gene. We detected allele loss in 27 of 70 breast tumour DNAs. Fifteen of these showed loss limited to a subregion of the area studied. The most commonly...

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Detalles Bibliográficos
Autores principales: Feilotter, H E, Coulon, V, McVeigh, J L, Boag, A H, Dorion-Bonnet, F, Duboué, B, Latham1, W C W, Eng, C, Mulligan, L M, Longy, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362663/
https://www.ncbi.nlm.nih.gov/pubmed/10070859
http://dx.doi.org/10.1038/sj.bjc.6690115

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