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Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours
The presence of a high number of infiltrating CD1a(+)cells in malignant neoplasms has been reported to be associated with an improved prognosis, reduced tumour recurrence and fewer metastases. This study identified a population of CD1a(+)cells within the lymphoid cell infiltrate in human ductal brea...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362664/ https://www.ncbi.nlm.nih.gov/pubmed/10070894 http://dx.doi.org/10.1038/sj.bjc.6690150 |
Sumario: | The presence of a high number of infiltrating CD1a(+)cells in malignant neoplasms has been reported to be associated with an improved prognosis, reduced tumour recurrence and fewer metastases. This study identified a population of CD1a(+)cells within the lymphoid cell infiltrate in human ductal breast carcinoma (n= 52), which was significantly different from normal breast tissue, in which only two out of nine cases expressed CD1a(+)cells (P= 0.0192). In the majority of cases, the infiltrate was low compared with the number of macrophages and T cells present (results not shown). There was no correlation between the number of CD1a(+)cells and tumour grade, with all tumour grades expressing similar numbers of infiltrating CD1a(+)cells. There was clear evidence, however, that the CD1a(+)cells were closely associated with tumour cells. It is likely that CD1a(+)cells have a role in antigen capture and presentation in human tumours, and this study documents the density of CD1a(+)cells in a large sample of all histological grades of human breast carcinomas. 1999 Cancer Research Campaign |
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