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Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours
The presence of a high number of infiltrating CD1a(+)cells in malignant neoplasms has been reported to be associated with an improved prognosis, reduced tumour recurrence and fewer metastases. This study identified a population of CD1a(+)cells within the lymphoid cell infiltrate in human ductal brea...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1999
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362664/ https://www.ncbi.nlm.nih.gov/pubmed/10070894 http://dx.doi.org/10.1038/sj.bjc.6690150 |
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author | Hillenbrand, E E Neville, A M Coventry, B J |
author_facet | Hillenbrand, E E Neville, A M Coventry, B J |
author_sort | Hillenbrand, E E |
collection | PubMed |
description | The presence of a high number of infiltrating CD1a(+)cells in malignant neoplasms has been reported to be associated with an improved prognosis, reduced tumour recurrence and fewer metastases. This study identified a population of CD1a(+)cells within the lymphoid cell infiltrate in human ductal breast carcinoma (n= 52), which was significantly different from normal breast tissue, in which only two out of nine cases expressed CD1a(+)cells (P= 0.0192). In the majority of cases, the infiltrate was low compared with the number of macrophages and T cells present (results not shown). There was no correlation between the number of CD1a(+)cells and tumour grade, with all tumour grades expressing similar numbers of infiltrating CD1a(+)cells. There was clear evidence, however, that the CD1a(+)cells were closely associated with tumour cells. It is likely that CD1a(+)cells have a role in antigen capture and presentation in human tumours, and this study documents the density of CD1a(+)cells in a large sample of all histological grades of human breast carcinomas. 1999 Cancer Research Campaign |
format | Text |
id | pubmed-2362664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23626642009-09-10 Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours Hillenbrand, E E Neville, A M Coventry, B J Br J Cancer Regular Article The presence of a high number of infiltrating CD1a(+)cells in malignant neoplasms has been reported to be associated with an improved prognosis, reduced tumour recurrence and fewer metastases. This study identified a population of CD1a(+)cells within the lymphoid cell infiltrate in human ductal breast carcinoma (n= 52), which was significantly different from normal breast tissue, in which only two out of nine cases expressed CD1a(+)cells (P= 0.0192). In the majority of cases, the infiltrate was low compared with the number of macrophages and T cells present (results not shown). There was no correlation between the number of CD1a(+)cells and tumour grade, with all tumour grades expressing similar numbers of infiltrating CD1a(+)cells. There was clear evidence, however, that the CD1a(+)cells were closely associated with tumour cells. It is likely that CD1a(+)cells have a role in antigen capture and presentation in human tumours, and this study documents the density of CD1a(+)cells in a large sample of all histological grades of human breast carcinomas. 1999 Cancer Research Campaign Nature Publishing Group 1999-02 /pmc/articles/PMC2362664/ /pubmed/10070894 http://dx.doi.org/10.1038/sj.bjc.6690150 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Hillenbrand, E E Neville, A M Coventry, B J Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours |
title | Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours |
title_full | Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours |
title_fullStr | Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours |
title_full_unstemmed | Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours |
title_short | Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours |
title_sort | immunohistochemical localization of cd1a-positive putative dendritic cells in human breast tumours |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362664/ https://www.ncbi.nlm.nih.gov/pubmed/10070894 http://dx.doi.org/10.1038/sj.bjc.6690150 |
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