Influence of O(6)-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice

Previous studies have demonstrated that novel molecular combinations of 5-fluorouracil (5FU) and 2-chloroethyl-1-nitrosourea (CNU) have good preclinical activity and may exert less myelotoxicity than the clinically used nitrosoureas such as 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). This study exa...

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Detalles Bibliográficos
Autores principales: Bibby, M C, Thompson, M J, Rafferty, J A, Margison, G P, McElhinney, R S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362701/
https://www.ncbi.nlm.nih.gov/pubmed/10188873
http://dx.doi.org/10.1038/sj.bjc.6690215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362701/
https://www.ncbi.nlm.nih.gov/pubmed/10188873
http://dx.doi.org/10.1038/sj.bjc.6690215

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