Cargando…

Influence of O(6)-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice

Previous studies have demonstrated that novel molecular combinations of 5-fluorouracil (5FU) and 2-chloroethyl-1-nitrosourea (CNU) have good preclinical activity and may exert less myelotoxicity than the clinically used nitrosoureas such as 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). This study exa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bibby, M C, Thompson, M J, Rafferty, J A, Margison, G P, McElhinney, R S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362701/ https://www.ncbi.nlm.nih.gov/pubmed/10188873 http://dx.doi.org/10.1038/sj.bjc.6690215

Ejemplares similares

The Sensitivity of Cells in Exponential and Stationary Phases of Growth to Bleomycin and to 1,3-bis(2-chloroethyl)-1-Nitrosourea
por: Twentyman, P. R., et al.
Publicado: (1973)

Potentiation of 1‐(2‐Chloroethyl)‐3‐cyclohexyl‐1‐nitrosourea's Toxicity in vitro by Two New Bioreductive Agents
por: Papadopoulou, Maria V., et al.
Publicado: (1992)

Enhanced Antitumor Activity and Reduced Toxicity of 1,3‐Bis(2‐chloroethyl)‐1‐nitrosourea Administered in Lipid Microspheres to Tumor‐bearing Mice
por: Takenaga, Mitsuko, et al.
Publicado: (1993)

The binding of 14C labelled 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) to macromolecules of sensitive and resistant tumours.
por: Connors, T. A., et al.
Publicado: (1974)

Over-representation of specific regions of chromosome 22 in cells from human glioma correlate with resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea
por: Hank, Nicole C, et al.
Publicado: (2006)

N,N’-Bis(2-chloroethyl)-N-nitrosourea (BCNU)-induced Apoptosis of Neural Progenitor Cells in the Developing Fetal Rat Brain
por: Yamaguchi, Tsuyoshi, et al.
Publicado: (2010)

1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance–fluorescence imaging for tracking of chemotherapeutic agents
por: Wei, Kuo-Chen, et al.
Publicado: (2016)

Tumour volume response, initial cell kill and cellular repopulation in B16 melanoma treated with cyclophosphamide and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
por: Stephens, T. C., et al.
Publicado: (1977)

Effects of BCG and 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) on the cytostatic activity of macrophages in normal and tumour-bearing rats.
por: Saijo, N., et al.
Publicado: (1980)

tert-Butyl N-[N,N-bis(2-chloroethyl)sulfamoyl]-N-(2-chloroethyl)carbamate
por: Seridi, Achour, et al.
Publicado: (2009)

Dichlorophosphinic bis(2-chloroethyl)amide
por: Song, Erqun, et al.
Publicado: (2012)

Enhancement by O6-benzyl-N2-acetylguanosine of N'-[2-chloroethyl]-N-[2-(methylsulphonyl)ethyl]-N'-nitrosourea therapeutic index on nude mice bearing resistant human melanoma.
por: Debiton, E., et al.
Publicado: (1997)

Reproductive toxicology. Tris(2-chloroethyl)phosphate.
Publicado: (1997)

4-(2-Chloroethyl)morpholinium picrate
por: Kant, Rajni, et al.
Publicado: (2009)

2-Chloroethyl 4-nitrobenzoate
por: Wu, Hao, et al.
Publicado: (2010)

Pre-clinical evaluation of a novel chloroethylating agent, Clomesone.
por: Matthew, A. M., et al.
Publicado: (1993)

REACTION OF ENZYMES AND PROTEINS WITH MUSTARD GAS (BIS(β-CHLOROETHYL)SULFIDE)
por: Herriott, Roger M., et al.
Publicado: (1946)

Lipopolysaccharide enhances the cytotoxicity of 2-chloroethyl ethyl sulfide
por: Stone, William L, et al.
Publicado: (2003)

Proceedings: Mechanism of action of tumour inhibitory nitrosoureas.
por: Connors, T. A., et al.
Publicado: (1975)

N-(2-Chloroethyl)pyrazine-2-carboxamide
por: da Silva Lima, Camilo H., et al.
Publicado: (2010)

4-[(2-Chloroethyl)amino]quinolinium chloride monohydrate
por: de Souza, Marcus V. N., et al.
Publicado: (2009)

The Effect of Urethanes and Di(2-chloroethyl) Methylamine Hydrochloride on the Autoxidation of Dopa
por: Lea, A. J.
Publicado: (1950)

N-(2-Chloroethyl)morpholine-4-carboxamide
por: Ujam, Oguejiofo T., et al.
Publicado: (2014)

Quaternarization and polymerization of 2-chloroethyl maleate derivative of epoxidized soybean oil
por: GÜRBÜZ, Demet
Publicado: (2022)

2-Chloroethyl 2-(5-bromo-3-methylsulfinyl-1-benzofuran-2-yl)acetate
por: Choi, Hong Dae, et al.
Publicado: (2009)

Discovery of N-(2-Aminophenyl)-4-(bis(2-chloroethyl)amino)Benzamide as a Potent Histone Deacetylase Inhibitor
por: Zhang, Lihui, et al.
Publicado: (2019)

O6-alkylguanine-DNA-alkyltransferase activity and nitrosourea sensitivity in human cancer cell lines.
por: Walker, M. C., et al.
Publicado: (1992)

Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureas.
por: Bodell, W J, et al.
Publicado: (1985)

(E)-2,4-Dichloro-6-{1-[(2-chloroethyl)imino]ethyl}phenol
por: Xie, Yong-Sheng, et al.
Publicado: (2010)

3-(2-Chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
por: Jasinski, Jerry P., et al.
Publicado: (2009)

SOLUBILITY OF MUSTARD GAS [BIS (β-CHLOROETHYL) SULFIDE] IN WATER, MOLAR SODIUM CHLORIDE, AND IN SOLUTIONS OF DETERGENTS
por: Herriott, Roger M.
Publicado: (1947)

Methimazole, an Effective Neutralizing Agent of the Sulfur Mustard Derivative 2-Chloroethyl Ethyl Sulfide
por: Armoo, Albert, et al.
Publicado: (2023)

Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli
por: Yamada, Yoko, et al.
Publicado: (2019)

Protective Effects of Recombinant Kunitz-Domain 1 of Human Tissue Factor Pathway Inhibitor-2 Against 2-Chloroethyl Ethyl Sulfide Toxicity In Vitro
por: Choi, Moonsuk S., et al.
Publicado: (2007)

Hypoxic cells and in situ chemopotentiation of the nitrosoureas by misonidazole.
por: Wheeler, K. T., et al.
Publicado: (1984)

1-(2-Chloroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
por: Khazi, Mohammed Iqbal A., et al.
Publicado: (2012)

Alleviation of Tris(2-chloroethyl) Phosphate Toxicity on the Marine Rotifer Brachionus plicatilis by Polystyrene Microplastics: Features and Molecular Evidence
por: Ma, Wenqian, et al.
Publicado: (2022)

Disposition of the prodrug 4-(bis (2-chloroethyl) amino) benzoyl-L-glutamic acid and its active parent drug in mice.
por: Antoniw, P., et al.
Publicado: (1990)

Influence of Glutathione and Glutathione S-transferases on DNA Interstrand Cross-Link Formation by 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the Active Anticancer Moiety Generated by Laromustine
por: Penketh, Philip G., et al.
Publicado: (2014)

Discovery of N-(2-Amino-4-Fluorophenyl)-4-[bis-(2-Chloroethyl)-Amino]-Benzamide as a Potent HDAC3 Inhibitor
por: Chen, Yiming, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dka07l3vbthnbciu4cfa3jp8i7