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Induction of apoptosis in myeloid leukaemic cells by ribozymes targeted against AML1/MTG8

The translocation (8;21)(q22;q22) is a karyotypic abnormality detected in acute myeloid leukaemia (AML) M2 and results in the formation of the chimeric fusion gene AML1/MTG8. We previously reported that two hammerhead ribozymes against AML1/MTG8 cleave this fusion transcript and also inhibit the pro...

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Detalles Bibliográficos
Autores principales:	Matsushita, H, Kizaki, M, Kobayashi, H, Muto, A, Ikeda, Y
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362727/ https://www.ncbi.nlm.nih.gov/pubmed/10188872 http://dx.doi.org/10.1038/sj.bjc.6690214

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