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Phase I study of Carzelesin (U-80,244) given (4-weekly) by intravenous bolus schedule

Carzelesin is a cyclopropylpyrroloindole analogue which acts as a DNA-sequence-specific alkylating agent. In this phase I study, Carzelesin was given as a 4-weekly 10 min IV infusion to 51 patients with advanced solid tumours. Patients received a median of two courses (range 1–5) at one of nine dose...

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Detalles Bibliográficos
Autores principales:	Awada, A, Punt, C J A, Piccart, M J, Tellingen, O Van, Manen, L Van, Kerger, J, Groot, Y, Wanders, J, Verweij, J, Wagener, D J Th
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362731/ https://www.ncbi.nlm.nih.gov/pubmed/10188890 http://dx.doi.org/10.1038/sj.bjc.6690232

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