New semisynthetic vinca alkaloids: chemical, biochemical and cellular studies

A new semisynthetic anti-tumour bis-indol compound, KAR-2 [3′-(β-chloroethyl)-2′,4′-dioxo-3,5′-spiro-oxazolidino-4-deacetoxy-vinblastine] with lower toxicity than vinca alkaloids used in chemotherapy binds to calmodulin but, in contrast to vinblastine, does not exhibit anti-calmodulin activity. To i...

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Detalles Bibliográficos
Autores principales: Orosz, F, Comin, B, Raïs, B, Puigjaner, J, Kovács, J, Tárkányi, G, Ács, T, Keve, T, Cascante, M, Ovádi, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362735/
https://www.ncbi.nlm.nih.gov/pubmed/10188876
http://dx.doi.org/10.1038/sj.bjc.6690218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362735/
https://www.ncbi.nlm.nih.gov/pubmed/10188876
http://dx.doi.org/10.1038/sj.bjc.6690218

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