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Randomized trial to compare the efficacy and toxicity of cyclophosphamide, methotrexate and 5-fluorouracil (CMF) with methotrexate mitoxantrone (MM) in advanced carcinoma of the breast

One hundred and sixteen patients with locally advanced or metastatic breast cancer were randomized to receive CMF (cyclophosphamide 600 mg m(−2) day 1 and 8 i.v., 5-fluorouracil 600 mg m(−2) day 1 and 8 i.v.,, methotrexate 40 mg m(−2) day 1 and 8 i.v., monthly for 6 cycles) or MM (methotrexate 30 mg...

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Detalles Bibliográficos
Autores principales:	Harper-Wynne, C, English, J, Meyer, L, Bower, M, Archer, C, Sinnett, H D, Lowdell, C, Coombes, R C
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362871/ https://www.ncbi.nlm.nih.gov/pubmed/10496359 http://dx.doi.org/10.1038/sj.bjc.6990694

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