Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization

We have examined 11 cases of childhood adrenocortical tumours for copy number changes using comparative genomic hybridization (CGH). The changes seen are highly consistent between cases, and are independent of tumour type (carcinoma versus adenoma) or the presence of a germline TP53 mutation. The re...

Descripción completa

Detalles Bibliográficos
Autores principales: James, L A, Kelsey, A M, Birch, J M, Varley, J M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362872/
https://www.ncbi.nlm.nih.gov/pubmed/10496356
http://dx.doi.org/10.1038/sj.bjc.6990691
_version_ 1782153562155909120
author James, L A
Kelsey, A M
Birch, J M
Varley, J M
author_facet James, L A
Kelsey, A M
Birch, J M
Varley, J M
author_sort James, L A
collection PubMed
description We have examined 11 cases of childhood adrenocortical tumours for copy number changes using comparative genomic hybridization (CGH). The changes seen are highly consistent between cases, and are independent of tumour type (carcinoma versus adenoma) or the presence of a germline TP53 mutation. The regions of chromosomal gain and loss identified in this study indicate the location of genes that are potentially important in the development and progression of childhood adrenocortical tumours. Finally, the copy number changes identified in childhood tumours are distinctly different to those seen in adult cases (Kjellman et al (1996) Cancer Res56: 4219–4223), and we propose that this indicates that childhood tumours are of embryonal origin. © 1999 Cancer Research Campaign
format Text
id pubmed-2362872
institution National Center for Biotechnology Information
language English
publishDate 1999
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23628722009-09-10 Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization James, L A Kelsey, A M Birch, J M Varley, J M Br J Cancer Regular Article We have examined 11 cases of childhood adrenocortical tumours for copy number changes using comparative genomic hybridization (CGH). The changes seen are highly consistent between cases, and are independent of tumour type (carcinoma versus adenoma) or the presence of a germline TP53 mutation. The regions of chromosomal gain and loss identified in this study indicate the location of genes that are potentially important in the development and progression of childhood adrenocortical tumours. Finally, the copy number changes identified in childhood tumours are distinctly different to those seen in adult cases (Kjellman et al (1996) Cancer Res56: 4219–4223), and we propose that this indicates that childhood tumours are of embryonal origin. © 1999 Cancer Research Campaign Nature Publishing Group 1999-09 /pmc/articles/PMC2362872/ /pubmed/10496356 http://dx.doi.org/10.1038/sj.bjc.6990691 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
James, L A
Kelsey, A M
Birch, J M
Varley, J M
Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization
title Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization
title_full Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization
title_fullStr Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization
title_full_unstemmed Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization
title_short Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization
title_sort highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362872/
https://www.ncbi.nlm.nih.gov/pubmed/10496356
http://dx.doi.org/10.1038/sj.bjc.6990691
work_keys_str_mv AT jamesla highlyconsistentgeneticalterationsinchildhoodadrenocorticaltumoursdetectedbycomparativegenomichybridization
AT kelseyam highlyconsistentgeneticalterationsinchildhoodadrenocorticaltumoursdetectedbycomparativegenomichybridization
AT birchjm highlyconsistentgeneticalterationsinchildhoodadrenocorticaltumoursdetectedbycomparativegenomichybridization
AT varleyjm highlyconsistentgeneticalterationsinchildhoodadrenocorticaltumoursdetectedbycomparativegenomichybridization

Ejemplares similares