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Proteolytic cleavage of p53 mutants in response to mismatched DNA

Interaction of p53 with mismatched DNA induces proteolytic cleavage with release of a 35-kDa protein fragment from the p53–DNA complexes. The 35-kDa cleavage product is activated for specific biochemical function(s) and may play a role in the cellular response to DNA damage (Molinari et al (1996) On...

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Detalles Bibliográficos
Autores principales:	Mee, T, Okorokov, A L, Metcalfe, S, Milner, J
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362880/ https://www.ncbi.nlm.nih.gov/pubmed/10496344 http://dx.doi.org/10.1038/sj.bjc.6690679

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