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Predictive value of expression of p16(INK4A), retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers

The predictive value of expression of p16(INK4A), retinoblastoma (Rb) and p53 proteins for prognosis was evaluated in 76 patients with non-small-cell lung cancers (NSCLCs) that were potentially curatively resected between 1990 and 1995, using the results of immunostaining analyses of these proteins...

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Autores principales: Hommura, F, Dosaka-Akita, H, Kinoshita, I, Mishina, T, Hiroumi, H, Ogura, S, Katoh, H, Kawakami, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362891/
https://www.ncbi.nlm.nih.gov/pubmed/10574258
http://dx.doi.org/10.1038/sj.bjc.6690750
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author Hommura, F
Dosaka-Akita, H
Kinoshita, I
Mishina, T
Hiroumi, H
Ogura, S
Katoh, H
Kawakami, Y
author_facet Hommura, F
Dosaka-Akita, H
Kinoshita, I
Mishina, T
Hiroumi, H
Ogura, S
Katoh, H
Kawakami, Y
author_sort Hommura, F
collection PubMed
description The predictive value of expression of p16(INK4A), retinoblastoma (Rb) and p53 proteins for prognosis was evaluated in 76 patients with non-small-cell lung cancers (NSCLCs) that were potentially curatively resected between 1990 and 1995, using the results of immunostaining analyses of these proteins as reported in our previous study (Kinoshita et al, 1996). Of these NSCLCs, 22 (29%) lacked p16 protein expression and eight (11%) Rb protein, while 30 (39%) showed positive (altered) p53 protein expression. Survival of patients with p16-negative tumours was not significantly different from that of patients with p16-positive tumours (5-year survival rates 67% and 72% respectively, P = 0.8), nor was survival of patients with Rb-negative tumours significantly different from that of patients with Rb-positive tumours (5-year survival rates 42% and 69% respectively, P = 0.9). Moreover, survival of patients with p16/Rb-negative (either p16- or Rb-negative) tumours was not significantly different from that of patients with p16/Rb-positive (both p16- and Rb-positive) tumours (5-year survival rates 67% and 68% respectively, P = 0.7). In contrast, survival of patients with p53-positive (altered) tumours tended to be shorter than that of patients with p53-negative (unaltered) tumours (5-year survival rates 56% and 78% respectively, P = 0.06). In univariate analysis of potential prognostic factors, p16, Rb and p16/Rb proteins were not significant prognostic factors in the present cohort of potentially curatively resected NSCLCs. Altered p53 protein status tended to be a negative prognostic factor (P = 0.06 by the univariate analysis). These results indicate that loss of p16 protein alone, or in combination with loss of Rb protein, does not predict the clinical outcome of patients with resected NSCLCs. © 1999 Cancer Research Campaign
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spelling pubmed-23628912009-09-10 Predictive value of expression of p16(INK4A), retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers Hommura, F Dosaka-Akita, H Kinoshita, I Mishina, T Hiroumi, H Ogura, S Katoh, H Kawakami, Y Br J Cancer Regular Article The predictive value of expression of p16(INK4A), retinoblastoma (Rb) and p53 proteins for prognosis was evaluated in 76 patients with non-small-cell lung cancers (NSCLCs) that were potentially curatively resected between 1990 and 1995, using the results of immunostaining analyses of these proteins as reported in our previous study (Kinoshita et al, 1996). Of these NSCLCs, 22 (29%) lacked p16 protein expression and eight (11%) Rb protein, while 30 (39%) showed positive (altered) p53 protein expression. Survival of patients with p16-negative tumours was not significantly different from that of patients with p16-positive tumours (5-year survival rates 67% and 72% respectively, P = 0.8), nor was survival of patients with Rb-negative tumours significantly different from that of patients with Rb-positive tumours (5-year survival rates 42% and 69% respectively, P = 0.9). Moreover, survival of patients with p16/Rb-negative (either p16- or Rb-negative) tumours was not significantly different from that of patients with p16/Rb-positive (both p16- and Rb-positive) tumours (5-year survival rates 67% and 68% respectively, P = 0.7). In contrast, survival of patients with p53-positive (altered) tumours tended to be shorter than that of patients with p53-negative (unaltered) tumours (5-year survival rates 56% and 78% respectively, P = 0.06). In univariate analysis of potential prognostic factors, p16, Rb and p16/Rb proteins were not significant prognostic factors in the present cohort of potentially curatively resected NSCLCs. Altered p53 protein status tended to be a negative prognostic factor (P = 0.06 by the univariate analysis). These results indicate that loss of p16 protein alone, or in combination with loss of Rb protein, does not predict the clinical outcome of patients with resected NSCLCs. © 1999 Cancer Research Campaign Nature Publishing Group 1999-10 /pmc/articles/PMC2362891/ /pubmed/10574258 http://dx.doi.org/10.1038/sj.bjc.6690750 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Hommura, F
Dosaka-Akita, H
Kinoshita, I
Mishina, T
Hiroumi, H
Ogura, S
Katoh, H
Kawakami, Y
Predictive value of expression of p16(INK4A), retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers
title Predictive value of expression of p16(INK4A), retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers
title_full Predictive value of expression of p16(INK4A), retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers
title_fullStr Predictive value of expression of p16(INK4A), retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers
title_full_unstemmed Predictive value of expression of p16(INK4A), retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers
title_short Predictive value of expression of p16(INK4A), retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers
title_sort predictive value of expression of p16(ink4a), retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362891/
https://www.ncbi.nlm.nih.gov/pubmed/10574258
http://dx.doi.org/10.1038/sj.bjc.6690750
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