Activation of cyclin D1-related kinase in human lung adenocarcinoma

Cyclin D1 gene amplification is an important event in many cancers, but it is rarely found in non-small-cell lung cancer (NSCLC). This study was conducted in an attempt to clarify any other mechanisms related to cyclin D1 involvement in the malignant transformation of NSCLC, and we clearly showed fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Igarashi, K, Masaki, T, Shiratori, Y, Rengifo, W, Nagata, T, Hara, K, Oka, T, Nakajima, J, Hisada, T, Hata, E, Omata, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362904/
https://www.ncbi.nlm.nih.gov/pubmed/10574260
http://dx.doi.org/10.1038/sj.bjc.6690752
Descripción
Sumario:Cyclin D1 gene amplification is an important event in many cancers, but it is rarely found in non-small-cell lung cancer (NSCLC). This study was conducted in an attempt to clarify any other mechanisms related to cyclin D1 involvement in the malignant transformation of NSCLC, and we clearly showed for the first time that cyclin D1-related kinases are activated in NSCLC, especially in adenocarcinoma but not in squamous cell carcinoma. The results of this study strongly suggest that enhanced cyclin D1-related kinase activity could contribute to a progression of adenocarcinoma in NSCLC. © 1999 Cancer Research Campaign

Ejemplares similares