Activation of cyclin D1-related kinase in human lung adenocarcinoma

Cyclin D1 gene amplification is an important event in many cancers, but it is rarely found in non-small-cell lung cancer (NSCLC). This study was conducted in an attempt to clarify any other mechanisms related to cyclin D1 involvement in the malignant transformation of NSCLC, and we clearly showed fo...

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Autores principales: Igarashi, K, Masaki, T, Shiratori, Y, Rengifo, W, Nagata, T, Hara, K, Oka, T, Nakajima, J, Hisada, T, Hata, E, Omata, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362904/
https://www.ncbi.nlm.nih.gov/pubmed/10574260
http://dx.doi.org/10.1038/sj.bjc.6690752
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author Igarashi, K
Masaki, T
Shiratori, Y
Rengifo, W
Nagata, T
Hara, K
Oka, T
Nakajima, J
Hisada, T
Hata, E
Omata, M
author_facet Igarashi, K
Masaki, T
Shiratori, Y
Rengifo, W
Nagata, T
Hara, K
Oka, T
Nakajima, J
Hisada, T
Hata, E
Omata, M
author_sort Igarashi, K
collection PubMed
description Cyclin D1 gene amplification is an important event in many cancers, but it is rarely found in non-small-cell lung cancer (NSCLC). This study was conducted in an attempt to clarify any other mechanisms related to cyclin D1 involvement in the malignant transformation of NSCLC, and we clearly showed for the first time that cyclin D1-related kinases are activated in NSCLC, especially in adenocarcinoma but not in squamous cell carcinoma. The results of this study strongly suggest that enhanced cyclin D1-related kinase activity could contribute to a progression of adenocarcinoma in NSCLC. © 1999 Cancer Research Campaign
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spelling pubmed-23629042009-09-10 Activation of cyclin D1-related kinase in human lung adenocarcinoma Igarashi, K Masaki, T Shiratori, Y Rengifo, W Nagata, T Hara, K Oka, T Nakajima, J Hisada, T Hata, E Omata, M Br J Cancer Regular Article Cyclin D1 gene amplification is an important event in many cancers, but it is rarely found in non-small-cell lung cancer (NSCLC). This study was conducted in an attempt to clarify any other mechanisms related to cyclin D1 involvement in the malignant transformation of NSCLC, and we clearly showed for the first time that cyclin D1-related kinases are activated in NSCLC, especially in adenocarcinoma but not in squamous cell carcinoma. The results of this study strongly suggest that enhanced cyclin D1-related kinase activity could contribute to a progression of adenocarcinoma in NSCLC. © 1999 Cancer Research Campaign Nature Publishing Group 1999-10 /pmc/articles/PMC2362904/ /pubmed/10574260 http://dx.doi.org/10.1038/sj.bjc.6690752 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Igarashi, K
Masaki, T
Shiratori, Y
Rengifo, W
Nagata, T
Hara, K
Oka, T
Nakajima, J
Hisada, T
Hata, E
Omata, M
Activation of cyclin D1-related kinase in human lung adenocarcinoma
title Activation of cyclin D1-related kinase in human lung adenocarcinoma
title_full Activation of cyclin D1-related kinase in human lung adenocarcinoma
title_fullStr Activation of cyclin D1-related kinase in human lung adenocarcinoma
title_full_unstemmed Activation of cyclin D1-related kinase in human lung adenocarcinoma
title_short Activation of cyclin D1-related kinase in human lung adenocarcinoma
title_sort activation of cyclin d1-related kinase in human lung adenocarcinoma
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362904/
https://www.ncbi.nlm.nih.gov/pubmed/10574260
http://dx.doi.org/10.1038/sj.bjc.6690752
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