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Effects of new 17α-hydroxylase/C(17,20)-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo

Our laboratory has been developing new inhibitors of a key regulatory enzyme of testicular and adrenal androgen synthesis 17α-hydroxylase/C(17,20)-lyase (P450c17), with the aim of improving prostate cancer treatment. We designed and evaluated two groups of azolyl steroids: Δ5-non-competitive inhibit...

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Detalles Bibliográficos
Autores principales:	Grigoryev, D N, Long, B J, Nnane, I P, Njar, V C O, Liu, Y, Brodie, A M H
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362906/ https://www.ncbi.nlm.nih.gov/pubmed/10574247 http://dx.doi.org/10.1038/sj.bjc.6690739

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