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Influence of stage at diagnosis on survival differences for rectal cancer in three European populations
Important differences have recently been highlighted between European countries in the survival of colorectal cancer patients. As data on stage at diagnosis were available for rectal cancers in three European population-based registries (Geneva Switzerland; Côte d'Or, France; Mallorca, Spain),...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1999
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362908/ https://www.ncbi.nlm.nih.gov/pubmed/10507771 http://dx.doi.org/10.1038/sj.bjc.6690716 |
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author | Monnet, E Faivre, J Raymond, L Garau, I |
author_facet | Monnet, E Faivre, J Raymond, L Garau, I |
author_sort | Monnet, E |
collection | PubMed |
description | Important differences have recently been highlighted between European countries in the survival of colorectal cancer patients. As data on stage at diagnosis were available for rectal cancers in three European population-based registries (Geneva Switzerland; Côte d'Or, France; Mallorca, Spain), we compared relative survival while assessing the effect of stage in a multiple regression model. We analysed 1005 rectal cancer cases diagnosed between 1982 and 1987 and followed up for at least 5 years. In the Mallorca registry, 16% of the patients were diagnosed in the TNM stage I (versus 21% in the Côte d'Or registry and 29% in the Geneva registry, P < 10(−4)) and the 5-year relative survival rate was lower (35%) than in the other two registries (Côte d’Or 47%, Geneva 48%, P = 0.01). In the multivariate analysis, stage was the only independent prognostic factor, whereas the excess death risk did not vary significantly among registries (compared to Geneva, Côte d'Or relative risk was 1.0, Mallorca relative risk 1.11, 95% confidence interval 0.76–1.32 and 0.85–1.44 respectively). Survival differences between the registries were mainly due to stage at diagnosis. Thus, diagnostic conditions appear to be the main determinant of the survival inequalities found in those three European populations. © 1999 Cancer Research Campaign |
format | Text |
id | pubmed-2362908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23629082009-09-10 Influence of stage at diagnosis on survival differences for rectal cancer in three European populations Monnet, E Faivre, J Raymond, L Garau, I Br J Cancer Regular Article Important differences have recently been highlighted between European countries in the survival of colorectal cancer patients. As data on stage at diagnosis were available for rectal cancers in three European population-based registries (Geneva Switzerland; Côte d'Or, France; Mallorca, Spain), we compared relative survival while assessing the effect of stage in a multiple regression model. We analysed 1005 rectal cancer cases diagnosed between 1982 and 1987 and followed up for at least 5 years. In the Mallorca registry, 16% of the patients were diagnosed in the TNM stage I (versus 21% in the Côte d'Or registry and 29% in the Geneva registry, P < 10(−4)) and the 5-year relative survival rate was lower (35%) than in the other two registries (Côte d’Or 47%, Geneva 48%, P = 0.01). In the multivariate analysis, stage was the only independent prognostic factor, whereas the excess death risk did not vary significantly among registries (compared to Geneva, Côte d'Or relative risk was 1.0, Mallorca relative risk 1.11, 95% confidence interval 0.76–1.32 and 0.85–1.44 respectively). Survival differences between the registries were mainly due to stage at diagnosis. Thus, diagnostic conditions appear to be the main determinant of the survival inequalities found in those three European populations. © 1999 Cancer Research Campaign Nature Publishing Group 1999-10 /pmc/articles/PMC2362908/ /pubmed/10507771 http://dx.doi.org/10.1038/sj.bjc.6690716 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Monnet, E Faivre, J Raymond, L Garau, I Influence of stage at diagnosis on survival differences for rectal cancer in three European populations |
title | Influence of stage at diagnosis on survival differences for rectal cancer in three European populations |
title_full | Influence of stage at diagnosis on survival differences for rectal cancer in three European populations |
title_fullStr | Influence of stage at diagnosis on survival differences for rectal cancer in three European populations |
title_full_unstemmed | Influence of stage at diagnosis on survival differences for rectal cancer in three European populations |
title_short | Influence of stage at diagnosis on survival differences for rectal cancer in three European populations |
title_sort | influence of stage at diagnosis on survival differences for rectal cancer in three european populations |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362908/ https://www.ncbi.nlm.nih.gov/pubmed/10507771 http://dx.doi.org/10.1038/sj.bjc.6690716 |
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