Effects of the protein kinase inhibitors wortmannin and KN62 on cellular radiosensitivity and radiation-activated S phase and G1/S checkpoints in normal human fibroblasts

Wortmannin is a potent inhibitor of phosphatidylinositol (PI) 3-kinase and PI 3-kinase-related proteins (e.g. ATM), but it does not inhibit the activity of purified calmodulin-dependent protein kinase II (CaMKII). In the present study, we compared the effects of wortmannin and the CaMKII inhibitor K...

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Detalles Bibliográficos
Autores principales: Enns, L, Murray, D, Mirzayans, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362948/
https://www.ncbi.nlm.nih.gov/pubmed/10576651
http://dx.doi.org/10.1038/sj.bjc.6690793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362948/
https://www.ncbi.nlm.nih.gov/pubmed/10576651
http://dx.doi.org/10.1038/sj.bjc.6690793

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