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Dose escalation and pharmacokinetic study of a humanized anti-HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer

We conducted a phase I pharmacokinetic dose escalation study of a recombinant humanized anti-p185(HER2) monoclonal antibody (MKC-454) in 18 patients with metastatic breast cancer refractory to chemotherapy. Three or six patients at each dose level received 1, 2, 4 and 8 mg kg(–1) of MKC-454 as 90-mi...

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Detalles Bibliográficos
Autores principales:	Tokuda, Y, Watanabe, T, Omuro, Y, Ando, M, Katsumata, N, Okumura, A, Ohta, M, Fujii, H, Sasaki, Y, Niwa, T
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362960/ https://www.ncbi.nlm.nih.gov/pubmed/10604742 http://dx.doi.org/10.1038/sj.bjc.6690343

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