Reversal of MDR1-associated resistance to topotecan by PAK-200S, a new dihydropyridine analogue, in human cancer cell lines

Recent data suggest that expression of the membrane P(170)-glycoprotein (P-gp) may confer resistance to the topoisomerase- I-interactive agent topotecan. The present study describes the cellular effects of a new dihydropyridine analogue, PAK-200S, on P-gp-mediated resistance to topotecan in human br...

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Detalles Bibliográficos
Autores principales: Vanhoefer, U, Müller, M R, Hilger, R A, Lindtner, B, Klaassen, U, Schleucher, N, Rustum, Y M, Seeber, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362978/
https://www.ncbi.nlm.nih.gov/pubmed/10604726
http://dx.doi.org/10.1038/sj.bjc.6694384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362978/
https://www.ncbi.nlm.nih.gov/pubmed/10604726
http://dx.doi.org/10.1038/sj.bjc.6694384

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