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Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis
Lymph node dissemination is a major prognostic factor in human cancer. However, the molecular mechanisms underlying lymph node metastasis are poorly understood. Recently, vascular endothelial growth factor-C (VEGF-C) was identified as a ligand for VEGF receptor-3 (VEGFR-3/Flt-4) and the expression o...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1999
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362987/ https://www.ncbi.nlm.nih.gov/pubmed/10390013 http://dx.doi.org/10.1038/sj.bjc.6690356 |
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author | Tsurusaki, T Kanda, S Sakai, H Kanetake, H Saito, Y Alitalo, K Koji, T |
author_facet | Tsurusaki, T Kanda, S Sakai, H Kanetake, H Saito, Y Alitalo, K Koji, T |
author_sort | Tsurusaki, T |
collection | PubMed |
description | Lymph node dissemination is a major prognostic factor in human cancer. However, the molecular mechanisms underlying lymph node metastasis are poorly understood. Recently, vascular endothelial growth factor-C (VEGF-C) was identified as a ligand for VEGF receptor-3 (VEGFR-3/Flt-4) and the expression of VEGFR-3 was found to be highly restricted to the lymphatic endothelial cells. In this report, we investigated the expression of VEGF-C and VEGFR-3 in human prostatic carcinoma tissue by using in situ hybridization and immunohistochemical staining respectively. Expression of VEGF-C mRNA in prostatic carcinoma was significantly higher in lymph node-positive group than in lymph node-negative group. In addition, the number of VEGFR-3-positive vessels was increased in stroma surrounding VEGF-C-positive prostatic carcinoma cells. These results suggest that the expression of VEGF-C in prostatic carcinoma cells is implicated in the lymph node metastasis. © 1999 Cancer Research Campaign |
format | Text |
id | pubmed-2362987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23629872009-09-10 Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis Tsurusaki, T Kanda, S Sakai, H Kanetake, H Saito, Y Alitalo, K Koji, T Br J Cancer Regular Article Lymph node dissemination is a major prognostic factor in human cancer. However, the molecular mechanisms underlying lymph node metastasis are poorly understood. Recently, vascular endothelial growth factor-C (VEGF-C) was identified as a ligand for VEGF receptor-3 (VEGFR-3/Flt-4) and the expression of VEGFR-3 was found to be highly restricted to the lymphatic endothelial cells. In this report, we investigated the expression of VEGF-C and VEGFR-3 in human prostatic carcinoma tissue by using in situ hybridization and immunohistochemical staining respectively. Expression of VEGF-C mRNA in prostatic carcinoma was significantly higher in lymph node-positive group than in lymph node-negative group. In addition, the number of VEGFR-3-positive vessels was increased in stroma surrounding VEGF-C-positive prostatic carcinoma cells. These results suggest that the expression of VEGF-C in prostatic carcinoma cells is implicated in the lymph node metastasis. © 1999 Cancer Research Campaign Nature Publishing Group 1999-04 /pmc/articles/PMC2362987/ /pubmed/10390013 http://dx.doi.org/10.1038/sj.bjc.6690356 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Tsurusaki, T Kanda, S Sakai, H Kanetake, H Saito, Y Alitalo, K Koji, T Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis |
title | Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis |
title_full | Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis |
title_fullStr | Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis |
title_full_unstemmed | Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis |
title_short | Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis |
title_sort | vascular endothelial growth factor-c expression in human prostatic carcinoma and its relationship to lymph node metastasis |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362987/ https://www.ncbi.nlm.nih.gov/pubmed/10390013 http://dx.doi.org/10.1038/sj.bjc.6690356 |
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