Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li–Fraumeni syndrome

We have analysed Li–Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family membe...

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Detalles Bibliográficos
Autores principales: Burt, E C, McGown, G, Thorncroft, M, James, L A, Birch, J M, Varley, J M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363026/
https://www.ncbi.nlm.nih.gov/pubmed/10389970
http://dx.doi.org/10.1038/sj.bjc.6690313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363026/
https://www.ncbi.nlm.nih.gov/pubmed/10389970
http://dx.doi.org/10.1038/sj.bjc.6690313

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