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Antisense oligonucleotides to class III β-tubulin sensitize drug-resistant cells to Taxol
A major impediment to the successful use of Taxol in the treatment of cancer is the development of drug resistance. The major cellular target of Taxol is the microtubule that is comprised of α- and β-tubulin heterodimers. Binding sites for Taxol have been delineated on the β-tubulin subunit that has...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
1999
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363042/ https://www.ncbi.nlm.nih.gov/pubmed/10362110 http://dx.doi.org/10.1038/sj.bjc.6690507 |