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Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma

p53 and Bcl-2 are two important factors related to apoptosis and tumorigenesis. In this study, a series of 52 cases of pancreatic carcinoma (PC) were investigated using an immunohistochemical assay to determine whether altered expression of Bcl-2 and p53 has an impact on the progression of this mali...

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Autores principales: Hu, Y-X, Watanabe, H, Ohtsubo, K, Yamaguchi, Y, Ha, A, Motoo, Y, Okai, T, Sawabu, N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363052/
https://www.ncbi.nlm.nih.gov/pubmed/10362119
http://dx.doi.org/10.1038/sj.bjc.6690466
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author Hu, Y-X
Watanabe, H
Ohtsubo, K
Yamaguchi, Y
Ha, A
Motoo, Y
Okai, T
Sawabu, N
author_facet Hu, Y-X
Watanabe, H
Ohtsubo, K
Yamaguchi, Y
Ha, A
Motoo, Y
Okai, T
Sawabu, N
author_sort Hu, Y-X
collection PubMed
description p53 and Bcl-2 are two important factors related to apoptosis and tumorigenesis. In this study, a series of 52 cases of pancreatic carcinoma (PC) were investigated using an immunohistochemical assay to determine whether altered expression of Bcl-2 and p53 has an impact on the progression of this malignancy. Cytoplasmic immunoreactivity for Bcl-2 and nuclear staining of p53 was found in 12 (23.1%) and 32 (63.5%) cases of PC respectively. Furthermore, an inverse correlation between the expression of p53 and Bcl-2 existed in this series (P < 0.01). In a subgroup, the proportion of tumours showing that p53-positive and Bcl-2-negative staining was increased with increasing histological grade and clinical stage (P < 0.05), and moreover, the survival period of those patients whose tumour had this staining was shorter than those with other staining patterns of combined p53 and Bcl-2 (P < 0.05). Therefore, it is concluded that simultaneously aberrant expression of Bcl-2 and p53 may confer PC with more malignant clinicopathological characteristics. © 1999 Cancer Research Campaign
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spelling pubmed-23630522009-09-10 Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma Hu, Y-X Watanabe, H Ohtsubo, K Yamaguchi, Y Ha, A Motoo, Y Okai, T Sawabu, N Br J Cancer Regular Article p53 and Bcl-2 are two important factors related to apoptosis and tumorigenesis. In this study, a series of 52 cases of pancreatic carcinoma (PC) were investigated using an immunohistochemical assay to determine whether altered expression of Bcl-2 and p53 has an impact on the progression of this malignancy. Cytoplasmic immunoreactivity for Bcl-2 and nuclear staining of p53 was found in 12 (23.1%) and 32 (63.5%) cases of PC respectively. Furthermore, an inverse correlation between the expression of p53 and Bcl-2 existed in this series (P < 0.01). In a subgroup, the proportion of tumours showing that p53-positive and Bcl-2-negative staining was increased with increasing histological grade and clinical stage (P < 0.05), and moreover, the survival period of those patients whose tumour had this staining was shorter than those with other staining patterns of combined p53 and Bcl-2 (P < 0.05). Therefore, it is concluded that simultaneously aberrant expression of Bcl-2 and p53 may confer PC with more malignant clinicopathological characteristics. © 1999 Cancer Research Campaign Nature Publishing Group 1999-06 /pmc/articles/PMC2363052/ /pubmed/10362119 http://dx.doi.org/10.1038/sj.bjc.6690466 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Hu, Y-X
Watanabe, H
Ohtsubo, K
Yamaguchi, Y
Ha, A
Motoo, Y
Okai, T
Sawabu, N
Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma
title Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma
title_full Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma
title_fullStr Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma
title_full_unstemmed Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma
title_short Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma
title_sort bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363052/
https://www.ncbi.nlm.nih.gov/pubmed/10362119
http://dx.doi.org/10.1038/sj.bjc.6690466
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