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PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma

Increased mortality of patients with oral cancer largely reflects the local and regional spread of the disease. The invasiveness of these tumours requires hydrolases which are regulated through AP-1-dependent transcriptional mechanisms. Since the amount/activity of transcription factors bound to the...

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Detalles Bibliográficos
Autores principales:	Simon, C, Hicks, M J, Nemechek, A J, Mehta, R, Jr, B W O'Malley, Goepfert, H, Flaitz, C M, Boyd, D
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363077/ https://www.ncbi.nlm.nih.gov/pubmed/10424744 http://dx.doi.org/10.1038/sj.bjc.6690537

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