Bcl10 is not a target for frequent mutation in human carcinomas

The recently described Bcl10 gene has been suggested to be a major target gene for inactivation in a variety of human cancers. In order to further evaluate the role of this gene in human adult malignancies, we have analysed a series of carcinomas for mutations in the Bcl10 gene. We have screened a p...

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Autores principales: Lambers, A R, Gumbs, C, Ali, S, Marks, J R, Iglehart, J D, Berchuck, A, Futreal, P A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363095/
https://www.ncbi.nlm.nih.gov/pubmed/10408401
http://dx.doi.org/10.1038/sj.bjc.6690564
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author Lambers, A R
Gumbs, C
Ali, S
Marks, J R
Iglehart, J D
Berchuck, A
Futreal, P A
author_facet Lambers, A R
Gumbs, C
Ali, S
Marks, J R
Iglehart, J D
Berchuck, A
Futreal, P A
author_sort Lambers, A R
collection PubMed
description The recently described Bcl10 gene has been suggested to be a major target gene for inactivation in a variety of human cancers. In order to further evaluate the role of this gene in human adult malignancies, we have analysed a series of carcinomas for mutations in the Bcl10 gene. We have screened a panel of 174 carcinoma samples in total, comprised of 47 breast, 36 epithelial ovarian, 36 endometrial, 12 cervical, 23 colorectal and 20 head/neck carcinomas, all unselected for grade or stage. This panel reflects, in part, tumours reported to have involvement of the 1p22 region of chromosome 1, the region harbouring the Bcl10 gene. No deleterious mutations were detected in any of the samples analysed, strongly suggesting that Bcl10 is not a common target for inactivation in adult malignancies and that BCL10 is not the gene targeted for frequent inactivation at 1p22. © 1999 Cancer Research Campaign
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spelling pubmed-23630952009-09-10 Bcl10 is not a target for frequent mutation in human carcinomas Lambers, A R Gumbs, C Ali, S Marks, J R Iglehart, J D Berchuck, A Futreal, P A Br J Cancer Regular Article The recently described Bcl10 gene has been suggested to be a major target gene for inactivation in a variety of human cancers. In order to further evaluate the role of this gene in human adult malignancies, we have analysed a series of carcinomas for mutations in the Bcl10 gene. We have screened a panel of 174 carcinoma samples in total, comprised of 47 breast, 36 epithelial ovarian, 36 endometrial, 12 cervical, 23 colorectal and 20 head/neck carcinomas, all unselected for grade or stage. This panel reflects, in part, tumours reported to have involvement of the 1p22 region of chromosome 1, the region harbouring the Bcl10 gene. No deleterious mutations were detected in any of the samples analysed, strongly suggesting that Bcl10 is not a common target for inactivation in adult malignancies and that BCL10 is not the gene targeted for frequent inactivation at 1p22. © 1999 Cancer Research Campaign Nature Publishing Group 1999-07 /pmc/articles/PMC2363095/ /pubmed/10408401 http://dx.doi.org/10.1038/sj.bjc.6690564 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Lambers, A R
Gumbs, C
Ali, S
Marks, J R
Iglehart, J D
Berchuck, A
Futreal, P A
Bcl10 is not a target for frequent mutation in human carcinomas
title Bcl10 is not a target for frequent mutation in human carcinomas
title_full Bcl10 is not a target for frequent mutation in human carcinomas
title_fullStr Bcl10 is not a target for frequent mutation in human carcinomas
title_full_unstemmed Bcl10 is not a target for frequent mutation in human carcinomas
title_short Bcl10 is not a target for frequent mutation in human carcinomas
title_sort bcl10 is not a target for frequent mutation in human carcinomas
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363095/
https://www.ncbi.nlm.nih.gov/pubmed/10408401
http://dx.doi.org/10.1038/sj.bjc.6690564
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