Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines

Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a l...

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Autores principales: Schothorst, E M van, Mohkamsing, S, Gurp, R J H L M van, Oosterhuis, J W, Saag, P T van der, Looijenga, L H J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363097/
https://www.ncbi.nlm.nih.gov/pubmed/10408400
http://dx.doi.org/10.1038/sj.bjc.6690563
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author Schothorst, E M van
Mohkamsing, S
Gurp, R J H L M van
Oosterhuis, J W
Saag, P T van der
Looijenga, L H J
author_facet Schothorst, E M van
Mohkamsing, S
Gurp, R J H L M van
Oosterhuis, J W
Saag, P T van der
Looijenga, L H J
author_sort Schothorst, E M van
collection PubMed
description Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a larger series of cell lines as well as primary TGCTs by single-strand conformation polymorphism and endonuclease restriction analysis. Because no aberrations were detected, we conclude that inactivation of Bcl10 by mutation is at least far less important in the development of TGCTs than proposed. © 1999 Cancer Research Campaign
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spelling pubmed-23630972009-09-10 Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines Schothorst, E M van Mohkamsing, S Gurp, R J H L M van Oosterhuis, J W Saag, P T van der Looijenga, L H J Br J Cancer Regular Article Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a larger series of cell lines as well as primary TGCTs by single-strand conformation polymorphism and endonuclease restriction analysis. Because no aberrations were detected, we conclude that inactivation of Bcl10 by mutation is at least far less important in the development of TGCTs than proposed. © 1999 Cancer Research Campaign Nature Publishing Group 1999-07 /pmc/articles/PMC2363097/ /pubmed/10408400 http://dx.doi.org/10.1038/sj.bjc.6690563 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Schothorst, E M van
Mohkamsing, S
Gurp, R J H L M van
Oosterhuis, J W
Saag, P T van der
Looijenga, L H J
Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines
title Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines
title_full Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines
title_fullStr Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines
title_full_unstemmed Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines
title_short Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines
title_sort lack of bcl10 mutations in testicular germ cell tumours and derived cell lines
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363097/
https://www.ncbi.nlm.nih.gov/pubmed/10408400
http://dx.doi.org/10.1038/sj.bjc.6690563
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