BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas

We have used single-strand conformation polymorphism (SSCP) analysis to screen for mutations in the BCL10 gene in 81 primary prostate carcinomas, 20 squamous cell cancers of the head and neck, 15 small-cell lung cancer cell lines, 24 renal carcinoma cell lines and 13 sarcoma cell lines. We failed to...

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Autores principales: Gill, S, Broni, J, Jefferies, S, Osin, P, Kovacs, G, Maitland, N J, Eeles, R, Edwards, S M, Dyer, M J S, Willis, T G, Cooper, C S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363098/
https://www.ncbi.nlm.nih.gov/pubmed/10408398
http://dx.doi.org/10.1038/sj.bjc.6690561
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author Gill, S
Broni, J
Jefferies, S
Osin, P
Kovacs, G
Maitland, N J
Eeles, R
Edwards, S M
Dyer, M J S
Willis, T G
Cooper, C S
author_facet Gill, S
Broni, J
Jefferies, S
Osin, P
Kovacs, G
Maitland, N J
Eeles, R
Edwards, S M
Dyer, M J S
Willis, T G
Cooper, C S
author_sort Gill, S
collection PubMed
description We have used single-strand conformation polymorphism (SSCP) analysis to screen for mutations in the BCL10 gene in 81 primary prostate carcinomas, 20 squamous cell cancers of the head and neck, 15 small-cell lung cancer cell lines, 24 renal carcinoma cell lines and 13 sarcoma cell lines. We failed to find evidence of somatically acquired mutations of the BCL10 gene suggesting that BCL10 does not play a major role in the development of these malignancies. © 1999 Cancer Research Campaign
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spelling pubmed-23630982009-09-10 BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas Gill, S Broni, J Jefferies, S Osin, P Kovacs, G Maitland, N J Eeles, R Edwards, S M Dyer, M J S Willis, T G Cooper, C S Br J Cancer Short Communication We have used single-strand conformation polymorphism (SSCP) analysis to screen for mutations in the BCL10 gene in 81 primary prostate carcinomas, 20 squamous cell cancers of the head and neck, 15 small-cell lung cancer cell lines, 24 renal carcinoma cell lines and 13 sarcoma cell lines. We failed to find evidence of somatically acquired mutations of the BCL10 gene suggesting that BCL10 does not play a major role in the development of these malignancies. © 1999 Cancer Research Campaign Nature Publishing Group 1999-07 /pmc/articles/PMC2363098/ /pubmed/10408398 http://dx.doi.org/10.1038/sj.bjc.6690561 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Gill, S
Broni, J
Jefferies, S
Osin, P
Kovacs, G
Maitland, N J
Eeles, R
Edwards, S M
Dyer, M J S
Willis, T G
Cooper, C S
BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas
title BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas
title_full BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas
title_fullStr BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas
title_full_unstemmed BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas
title_short BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas
title_sort bcl10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363098/
https://www.ncbi.nlm.nih.gov/pubmed/10408398
http://dx.doi.org/10.1038/sj.bjc.6690561
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