Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α(1)-acid glycoprotein binding

Dipyridamole has been shown to enhance the in vitro activity of antimetabolite anticancer drugs through the inhibition of nucleoside transport. However, the clinical potential of dipyridamole has not been realized because of the avid binding of the drug to the plasma protein α(1)-acid glycoprotein (...

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Detalles Bibliográficos
Autores principales: Curtin, N J, Bowman, K J, Turner, R N, Huang, B, Loughlin, P J, Calvert, A H, Golding, B T, Griffin, R J, Newell, D R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363125/
https://www.ncbi.nlm.nih.gov/pubmed/10468290
http://dx.doi.org/10.1038/sj.bjc.6690591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363125/
https://www.ncbi.nlm.nih.gov/pubmed/10468290
http://dx.doi.org/10.1038/sj.bjc.6690591

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