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Acidic environment causes apoptosis by increasing caspase activity

An exposure of HL-60 human promyelocytic leukaemia cells to acidic media with pH 6.2–6.6 caused an up-regulation of Bax protein expression within 2 h, which lasted for longer than 6 h. On the other hand, the apoptosis, as judged from PARP cleavage, DNA fragmentation and flow cytometric determination...

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Detalles Bibliográficos
Autores principales:	Park, H J, Lyons, J C, Ohtsubo, T, Song, C W
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363148/ https://www.ncbi.nlm.nih.gov/pubmed/10471036 http://dx.doi.org/10.1038/sj.bjc.6690617

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