Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer

Epidemiological evidence points to an increased risk of breast cancer in ataxia telangiectasia (AT) heterozygote women. Previous attempts to screen early onset or familial breast cancer patients failed to confirm an association. The issue of AT and late onset sporadic breast cancer remained unresolv...

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Detalles Bibliográficos
Autores principales: Bebb, D G, Yu, Z, Chen, J, Telatar, M, Gelmon, K, Phillips, N, Gatti, R A, Glickman, B W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363154/
https://www.ncbi.nlm.nih.gov/pubmed/10471049
http://dx.doi.org/10.1038/sj.bjc.6690630
Descripción
Sumario:Epidemiological evidence points to an increased risk of breast cancer in ataxia telangiectasia (AT) heterozygote women. Previous attempts to screen early onset or familial breast cancer patients failed to confirm an association. The issue of AT and late onset sporadic breast cancer remained unresolved. We screened 47 women who developed later onset, sporadic breast cancer for ataxia telangiectasia mutated (ATM) mutations. No mutations were found. © 1999 Cancer Research Campaign

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