Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization

Thirty-five hepatocellular carcinomas (HCCs) associated with hepatitis C virus (HCV) were analysed by comparative genomic hybridization (CGH), to screen for changes in copy-number of DNA sequences. Chromosomal losses were noted in 1p34–36 (37%), 4q12–21 (48%), 5q13–21 (35%), 6q13–16 (23%), 8p21–23 (...

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Autores principales: Sakakura, C, Hagiwara, A, Taniguchi, H, Yamaguchi, T, Yamagishi, H, Takahashi, T, Koyama, K, Nakamura, Y, Abe, T, Inazawa, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363156/
https://www.ncbi.nlm.nih.gov/pubmed/10471057
http://dx.doi.org/10.1038/sj.bjc.6690638
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author Sakakura, C
Hagiwara, A
Taniguchi, H
Yamaguchi, T
Yamagishi, H
Takahashi, T
Koyama, K
Nakamura, Y
Abe, T
Inazawa, J
author_facet Sakakura, C
Hagiwara, A
Taniguchi, H
Yamaguchi, T
Yamagishi, H
Takahashi, T
Koyama, K
Nakamura, Y
Abe, T
Inazawa, J
author_sort Sakakura, C
collection PubMed
description Thirty-five hepatocellular carcinomas (HCCs) associated with hepatitis C virus (HCV) were analysed by comparative genomic hybridization (CGH), to screen for changes in copy-number of DNA sequences. Chromosomal losses were noted in 1p34–36 (37%), 4q12–21 (48%), 5q13–21 (35%), 6q13–16 (23%), 8p21–23 (28%), 13q (20%), 16q (33%) and 17p13 (37%). Gains were noted in 1q (46%), 6p (20%), 8q21–24 (31%) and 17q (43%). High level gains indicative of gene amplifications were found in 7q31 (3%), 11q13 (3%), 14q12 (6%) and 17q12 (3%); amplification at 14q12 may be characteristic for HCCs. No significant difference in chromosomal aberrations was noted between carcinomas associated with HCV-infection in our study and those reported earlier in HCCs infected with hepatitis B virus (HBV), indicating that both HBV- and HCV-related carcinomas may progress through a similar cascade of molecular events. © 1999 Cancer Research Campaign
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spelling pubmed-23631562009-09-10 Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization Sakakura, C Hagiwara, A Taniguchi, H Yamaguchi, T Yamagishi, H Takahashi, T Koyama, K Nakamura, Y Abe, T Inazawa, J Br J Cancer Regular Article Thirty-five hepatocellular carcinomas (HCCs) associated with hepatitis C virus (HCV) were analysed by comparative genomic hybridization (CGH), to screen for changes in copy-number of DNA sequences. Chromosomal losses were noted in 1p34–36 (37%), 4q12–21 (48%), 5q13–21 (35%), 6q13–16 (23%), 8p21–23 (28%), 13q (20%), 16q (33%) and 17p13 (37%). Gains were noted in 1q (46%), 6p (20%), 8q21–24 (31%) and 17q (43%). High level gains indicative of gene amplifications were found in 7q31 (3%), 11q13 (3%), 14q12 (6%) and 17q12 (3%); amplification at 14q12 may be characteristic for HCCs. No significant difference in chromosomal aberrations was noted between carcinomas associated with HCV-infection in our study and those reported earlier in HCCs infected with hepatitis B virus (HBV), indicating that both HBV- and HCV-related carcinomas may progress through a similar cascade of molecular events. © 1999 Cancer Research Campaign Nature Publishing Group 1999-08 /pmc/articles/PMC2363156/ /pubmed/10471057 http://dx.doi.org/10.1038/sj.bjc.6690638 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Sakakura, C
Hagiwara, A
Taniguchi, H
Yamaguchi, T
Yamagishi, H
Takahashi, T
Koyama, K
Nakamura, Y
Abe, T
Inazawa, J
Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization
title Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization
title_full Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization
title_fullStr Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization
title_full_unstemmed Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization
title_short Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization
title_sort chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis c virus infection detected by comparative genomic hybridization
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363156/
https://www.ncbi.nlm.nih.gov/pubmed/10471057
http://dx.doi.org/10.1038/sj.bjc.6690638
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