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Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours
We recently discovered that stathmin was overexpressed in a subgroup of human breast carcinomas. Stathmin is a cytosolic phosphoprotein proposed to act as a relay integrating diverse cell signalling pathways, notably during the control of cell growth and differentiation. It may also be considered as...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363189/ https://www.ncbi.nlm.nih.gov/pubmed/10638981 http://dx.doi.org/10.1054/bjoc.1999.0891 |
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author | Curmi, P A Noguès, C Lachkar, S Carelle, N Gonthier, M-P Sobel, A Lidereau, R Bièche, I |
author_facet | Curmi, P A Noguès, C Lachkar, S Carelle, N Gonthier, M-P Sobel, A Lidereau, R Bièche, I |
author_sort | Curmi, P A |
collection | PubMed |
description | We recently discovered that stathmin was overexpressed in a subgroup of human breast carcinomas. Stathmin is a cytosolic phosphoprotein proposed to act as a relay integrating diverse cell signalling pathways, notably during the control of cell growth and differentiation. It may also be considered as one of the key regulators of cell division for its ability to destabilize microtubules in a phosphorylation-dependent manner. To assess the significance of stathmin overexpression in breast cancer, we evaluated the correlation of stathmin expression, quantified by reverse transcription polymerase chain reaction, with several disease parameters in a large series of human primary breast cancer (n = 133), obtained in strictly followed up women, whose clinico-pathological data were fully available. In agreement with our preliminary survey, stathmin was found overexpressed in a subgroup of tumours (22%). In addition, overexpression was correlated to the loss of steroid receptors (oestrogen, P = 0.0006; progesterone, P = 0.008), and to the Scarff–Bloom–Richardson histopathological grade III (P = 0.002), this latter being ascribable to the mitotic index component (P = 0.02). Furthermore studies at the DNA level indicated that stathmin is overexpressed irrespective of its genomic status. Our findings raise important questions concerning the causes and consequences of stathmin overexpression, and the reasons of its inability to counteract cell proliferation in the overexpression group. © 2000 Cancer Research Campaign |
format | Text |
id | pubmed-2363189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23631892009-09-10 Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours Curmi, P A Noguès, C Lachkar, S Carelle, N Gonthier, M-P Sobel, A Lidereau, R Bièche, I Br J Cancer Regular Article We recently discovered that stathmin was overexpressed in a subgroup of human breast carcinomas. Stathmin is a cytosolic phosphoprotein proposed to act as a relay integrating diverse cell signalling pathways, notably during the control of cell growth and differentiation. It may also be considered as one of the key regulators of cell division for its ability to destabilize microtubules in a phosphorylation-dependent manner. To assess the significance of stathmin overexpression in breast cancer, we evaluated the correlation of stathmin expression, quantified by reverse transcription polymerase chain reaction, with several disease parameters in a large series of human primary breast cancer (n = 133), obtained in strictly followed up women, whose clinico-pathological data were fully available. In agreement with our preliminary survey, stathmin was found overexpressed in a subgroup of tumours (22%). In addition, overexpression was correlated to the loss of steroid receptors (oestrogen, P = 0.0006; progesterone, P = 0.008), and to the Scarff–Bloom–Richardson histopathological grade III (P = 0.002), this latter being ascribable to the mitotic index component (P = 0.02). Furthermore studies at the DNA level indicated that stathmin is overexpressed irrespective of its genomic status. Our findings raise important questions concerning the causes and consequences of stathmin overexpression, and the reasons of its inability to counteract cell proliferation in the overexpression group. © 2000 Cancer Research Campaign Nature Publishing Group 2000-01 1999-12-08 /pmc/articles/PMC2363189/ /pubmed/10638981 http://dx.doi.org/10.1054/bjoc.1999.0891 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Curmi, P A Noguès, C Lachkar, S Carelle, N Gonthier, M-P Sobel, A Lidereau, R Bièche, I Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours |
title | Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours |
title_full | Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours |
title_fullStr | Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours |
title_full_unstemmed | Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours |
title_short | Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours |
title_sort | overexpression of stathmin in breast carcinomas points out to highly proliferative tumours |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363189/ https://www.ncbi.nlm.nih.gov/pubmed/10638981 http://dx.doi.org/10.1054/bjoc.1999.0891 |
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