Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy

Autoantibodies to the heat shock protein 90 (Hsp 90) have been reported as prognostic marker in breast cancer patients. Sera from 20 high-grade osteosarcoma patients were tested at the time of diagnosis by enzyme-linked immunosorbent assay. Presence of anti-Hsp90 antibodies correlated with a better...

Descripción completa

Detalles Bibliográficos
Autores principales: Trieb, K, Gerth, R, Holzer, G, Grohs, J G, Berger, P, Kotz, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363193/
https://www.ncbi.nlm.nih.gov/pubmed/10638971
http://dx.doi.org/10.1054/bjoc.1999.0881
_version_ 1782153643044110336
author Trieb, K
Gerth, R
Holzer, G
Grohs, J G
Berger, P
Kotz, R
author_facet Trieb, K
Gerth, R
Holzer, G
Grohs, J G
Berger, P
Kotz, R
author_sort Trieb, K
collection PubMed
description Autoantibodies to the heat shock protein 90 (Hsp 90) have been reported as prognostic marker in breast cancer patients. Sera from 20 high-grade osteosarcoma patients were tested at the time of diagnosis by enzyme-linked immunosorbent assay. Presence of anti-Hsp90 antibodies correlated with a better response to neoadjuvant chemotherapy (P< 0.01), whereas the absence correlated with development of metastases. These data suggest that anti-Hsp90 antibodies might be of predictive value in human osteosarcoma. © 2000 Cancer Research Campaign
format Text
id pubmed-2363193
institution National Center for Biotechnology Information
language English
publishDate 2000
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23631932009-09-10 Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy Trieb, K Gerth, R Holzer, G Grohs, J G Berger, P Kotz, R Br J Cancer Short Communication Autoantibodies to the heat shock protein 90 (Hsp 90) have been reported as prognostic marker in breast cancer patients. Sera from 20 high-grade osteosarcoma patients were tested at the time of diagnosis by enzyme-linked immunosorbent assay. Presence of anti-Hsp90 antibodies correlated with a better response to neoadjuvant chemotherapy (P< 0.01), whereas the absence correlated with development of metastases. These data suggest that anti-Hsp90 antibodies might be of predictive value in human osteosarcoma. © 2000 Cancer Research Campaign Nature Publishing Group 2000-01 1999-12-08 /pmc/articles/PMC2363193/ /pubmed/10638971 http://dx.doi.org/10.1054/bjoc.1999.0881 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Trieb, K
Gerth, R
Holzer, G
Grohs, J G
Berger, P
Kotz, R
Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy
title Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy
title_full Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy
title_fullStr Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy
title_full_unstemmed Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy
title_short Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy
title_sort antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363193/
https://www.ncbi.nlm.nih.gov/pubmed/10638971
http://dx.doi.org/10.1054/bjoc.1999.0881
work_keys_str_mv AT triebk antibodiestoheatshockprotein90inosteosarcomapatientscorrelatewithresponsetoneoadjuvantchemotherapy
AT gerthr antibodiestoheatshockprotein90inosteosarcomapatientscorrelatewithresponsetoneoadjuvantchemotherapy
AT holzerg antibodiestoheatshockprotein90inosteosarcomapatientscorrelatewithresponsetoneoadjuvantchemotherapy
AT grohsjg antibodiestoheatshockprotein90inosteosarcomapatientscorrelatewithresponsetoneoadjuvantchemotherapy
AT bergerp antibodiestoheatshockprotein90inosteosarcomapatientscorrelatewithresponsetoneoadjuvantchemotherapy
AT kotzr antibodiestoheatshockprotein90inosteosarcomapatientscorrelatewithresponsetoneoadjuvantchemotherapy

Ejemplares similares