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CD3 directed bispecific antibodies induce increased lymphocyte–endothelial cell interactions in vitro
Bispecific antibody (BsMAb) BIS-1 has been developed to redirect the cytolytic activity of cytotoxic T lymphocytes (CTL) to epithelial glycoprotein-2 (EGP-2) expressing tumour cells. Intravenous administration of BIS-1 F(ab′)(2)to carcinoma patients in a phase I/II clinical trial, caused immunomodul...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2000
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363284/ https://www.ncbi.nlm.nih.gov/pubmed/10646907 http://dx.doi.org/10.1054/bjoc.1999.0945 |