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Effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases
Abnormally low intramuscular glutamate and glutathione (GSH) levels and/or a decreased muscular uptake of glutamate by the skeletal muscle tissue have previously been found in malignant diseases and simian immunodeficiency virus (SIV) infection and may contribute to the development of cachexia. We t...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363291/ https://www.ncbi.nlm.nih.gov/pubmed/10646895 http://dx.doi.org/10.1054/bjoc.1999.0933 |
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author | Breitkreutz, R Babylon, A Hack, V Schuster, K Tokus, M Böhles, H Hagmüller, E Edler, L Holm, E Dröge, W |
author_facet | Breitkreutz, R Babylon, A Hack, V Schuster, K Tokus, M Böhles, H Hagmüller, E Edler, L Holm, E Dröge, W |
author_sort | Breitkreutz, R |
collection | PubMed |
description | Abnormally low intramuscular glutamate and glutathione (GSH) levels and/or a decreased muscular uptake of glutamate by the skeletal muscle tissue have previously been found in malignant diseases and simian immunodeficiency virus (SIV) infection and may contribute to the development of cachexia. We tested the hypothesis that an impaired mitochondrial energy metabolism may compromise the Na(+)-dependent glutamate transport. A randomized double-blind clinical trial was designed to study the effects of L -carnitine, i.e. an agent known to enhance mitochondrial integrity and function, on the glutamate transport and plasma glutamate level of cancer patients. The effect of carnitine on the intramuscular glutamate and GSH levels was examined in complementary experiments with tumour-bearing mice. In the mice, L -carnitine treatment ameliorated indeed the tumour-induced decrease in muscular glutamate and GSH levels and the increase in plasma glutamate levels. The carnitine-treated group in the randomized clinical study showed also a significant decrease in the plasma glutamate levels but only a moderate and statistically not significant increase in the relative glutamate uptake in the lower extremities. Further studies may be warranted to determine the effect of L -carnitine on the intramuscular GSH levels in cancer patients. © 2000 Cancer Research Campaign |
format | Text |
id | pubmed-2363291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23632912009-09-10 Effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases Breitkreutz, R Babylon, A Hack, V Schuster, K Tokus, M Böhles, H Hagmüller, E Edler, L Holm, E Dröge, W Br J Cancer Regular Article Abnormally low intramuscular glutamate and glutathione (GSH) levels and/or a decreased muscular uptake of glutamate by the skeletal muscle tissue have previously been found in malignant diseases and simian immunodeficiency virus (SIV) infection and may contribute to the development of cachexia. We tested the hypothesis that an impaired mitochondrial energy metabolism may compromise the Na(+)-dependent glutamate transport. A randomized double-blind clinical trial was designed to study the effects of L -carnitine, i.e. an agent known to enhance mitochondrial integrity and function, on the glutamate transport and plasma glutamate level of cancer patients. The effect of carnitine on the intramuscular glutamate and GSH levels was examined in complementary experiments with tumour-bearing mice. In the mice, L -carnitine treatment ameliorated indeed the tumour-induced decrease in muscular glutamate and GSH levels and the increase in plasma glutamate levels. The carnitine-treated group in the randomized clinical study showed also a significant decrease in the plasma glutamate levels but only a moderate and statistically not significant increase in the relative glutamate uptake in the lower extremities. Further studies may be warranted to determine the effect of L -carnitine on the intramuscular GSH levels in cancer patients. © 2000 Cancer Research Campaign Nature Publishing Group 2000-01 2000-01-18 /pmc/articles/PMC2363291/ /pubmed/10646895 http://dx.doi.org/10.1054/bjoc.1999.0933 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Breitkreutz, R Babylon, A Hack, V Schuster, K Tokus, M Böhles, H Hagmüller, E Edler, L Holm, E Dröge, W Effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases |
title | Effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases |
title_full | Effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases |
title_fullStr | Effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases |
title_full_unstemmed | Effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases |
title_short | Effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases |
title_sort | effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363291/ https://www.ncbi.nlm.nih.gov/pubmed/10646895 http://dx.doi.org/10.1054/bjoc.1999.0933 |
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